|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2003-3-19
|
|
pubmed:abstractText |
The introduction of a hydroxyl group into the 5-position of the diaryl furanone system provides highly selective inhibitors of cyclooxygenase-2. These molecules can be converted into their sodium salts which are water soluble, facilitating intravenous formulation. These salts show excellent potency in rat models of pain, fever and inflammation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:BlackW CameronWC,
pubmed-author:BrideauChristineC,
pubmed-author:ChanChi ChungCC,
pubmed-author:CharlesonStellaS,
pubmed-author:CromlishWandaW,
pubmed-author:GordonRobertR,
pubmed-author:GrimmErich LEL,
pubmed-author:HughesGregoryG,
pubmed-author:LegerSergeS,
pubmed-author:LiChun SingCS,
pubmed-author:PrasitPetpiboonP,
pubmed-author:RiendeauDenisD,
pubmed-author:ThérienMichelM,
pubmed-author:WangZhaoyinZ,
pubmed-author:XuLi JingLJ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
24
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1195-8
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:12643942-Animals,
pubmed-meshheading:12643942-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:12643942-Arthritis, Experimental,
pubmed-meshheading:12643942-CHO Cells,
pubmed-meshheading:12643942-Chemistry, Physical,
pubmed-meshheading:12643942-Cricetinae,
pubmed-meshheading:12643942-Cyclooxygenase 2,
pubmed-meshheading:12643942-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12643942-Cyclooxygenase Inhibitors,
pubmed-meshheading:12643942-Edema,
pubmed-meshheading:12643942-Fever,
pubmed-meshheading:12643942-Furans,
pubmed-meshheading:12643942-Humans,
pubmed-meshheading:12643942-Isoenzymes,
pubmed-meshheading:12643942-Membrane Proteins,
pubmed-meshheading:12643942-Pain,
pubmed-meshheading:12643942-Physicochemical Phenomena,
pubmed-meshheading:12643942-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12643942-Rats,
pubmed-meshheading:12643942-Solubility,
pubmed-meshheading:12643942-Structure-Activity Relationship,
pubmed-meshheading:12643942-Substrate Specificity
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
|
|
pubmed:affiliation |
Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8. blackc@merck.com
|
|
pubmed:publicationType |
Journal Article
|
