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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
6
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pubmed:dateCreated |
2003-3-19
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pubmed:abstractText |
A series of sulfamate surrogates of methionyl and isoleucyl adenylate have been investigated as MetRS and IleRS inhibitors by modifications of the sulfamate linker and adenine moieties. The discovery of 2-iodo Ile-NHSO(2)-AMP (58) as a potent Escherichia coli IleRS inhibitor revealed that a significant hydrophobic interaction between the 2-substituent of Ile-NHSO(2)-AMP and the adenine binding site of IleRS provided its high potency to the enzyme.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
13
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1087-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12643918-Binding Sites,
pubmed-meshheading:12643918-Enzyme Inhibitors,
pubmed-meshheading:12643918-Escherichia coli,
pubmed-meshheading:12643918-Indicators and Reagents,
pubmed-meshheading:12643918-Isoleucine-tRNA Ligase,
pubmed-meshheading:12643918-Methionine-tRNA Ligase,
pubmed-meshheading:12643918-Models, Molecular,
pubmed-meshheading:12643918-Molecular Conformation,
pubmed-meshheading:12643918-Sulfonamides,
pubmed-meshheading:12643918-Sulfonic Acids,
pubmed-meshheading:12643918-Thermus thermophilus
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
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pubmed:affiliation |
Laboratory of Medicinal Chemistry, RIPS, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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