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pubmed:abstractText |
The newly synthesized linoleic acid derivative, FR236924, induces a long-lasting facilitation of hippocampal neurotransmission based on a persistent enhancement in the activity of presynaptic nicotinic ACh receptors via a PKC pathway and the ensuing increase in glutamate release, not only in vitro but in vivo at a low dosage (2mg/kg, ip), which suggested the possibility of its use as a promising anti-dementia drug.
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pubmed:affiliation |
Molecular Science, Exploratory Res. Lab., Fujisawa Pharmaceutical Co. Ltd., 5-2-3 Tokodai, Tsukuba, Japan. tanaka-a@reprori.jp
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