Source:http://linkedlifedata.com/resource/pubmed/id/12643621
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-3-19
|
| pubmed:abstractText |
The mode of presentation of celiac disease in the United States is not known. We investigated the demographic and clinical features of 227 patients with biopsy-proven celiac disease and determined if there had been changes over time. The patients had been entered into a database; those seen prior to 1990 were retrospectively entered while those seen subsequently were prospectively entered. A "symptomatic" presentation described the "classical" presentation of celiac disease with prominent gastrointestinal symptoms: diarrhea and weight loss. Females were younger and had a longer duration of symptoms compared to males. The modes of presentation were symptomatic (62%), anemia or reduced bone density (15%), screening first-degree relatives (13%), and incidental diagnosis at endoscopy (8%). We compared those diagnosed before and after 1993 (when serologic testing was first used), and noted a reduction in those presenting with diarrhea, 73% vs 43% (P = 0.0001) and a reduction in the duration of symptoms, from 9.0 +/- 1.1 years to 4.4 +/- 0.6 years (P < 0001). In conclusion, the percentage of celiac disease patients presenting with diarrhea has decreased, probably related to the more widespread use of serologic testing for celiac disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0163-2116
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
48
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
395-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12643621-Adolescent,
pubmed-meshheading:12643621-Adult,
pubmed-meshheading:12643621-Age Distribution,
pubmed-meshheading:12643621-Aged,
pubmed-meshheading:12643621-Aged, 80 and over,
pubmed-meshheading:12643621-Biopsy, Needle,
pubmed-meshheading:12643621-Celiac Disease,
pubmed-meshheading:12643621-Cohort Studies,
pubmed-meshheading:12643621-Diarrhea,
pubmed-meshheading:12643621-Disease Progression,
pubmed-meshheading:12643621-Female,
pubmed-meshheading:12643621-Follow-Up Studies,
pubmed-meshheading:12643621-Humans,
pubmed-meshheading:12643621-Incidence,
pubmed-meshheading:12643621-Male,
pubmed-meshheading:12643621-Middle Aged,
pubmed-meshheading:12643621-Probability,
pubmed-meshheading:12643621-Retrospective Studies,
pubmed-meshheading:12643621-Risk Factors,
pubmed-meshheading:12643621-Severity of Illness Index,
pubmed-meshheading:12643621-Sex Distribution,
pubmed-meshheading:12643621-Time Factors,
pubmed-meshheading:12643621-Weight Loss
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Changing presentation of adult celiac disease.
|
| pubmed:affiliation |
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|