Linked Life Data

12642505

Source:http://linkedlifedata.com/resource/pubmed/id/12642505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-4-4
pubmed:abstractText
The renin-angiotensin (ANG) system has been implicated in the development of hypertension in spontaneously hypertensive rats (SHR). Because SHR are more susceptible to stress than normotensive Wistar-Kyoto rats (WKY), we measured the mRNA expression of AT1A, AT1B, and AT2 receptors in the hypothalamo-pituitary-adrenal (stress) axis of male SHR in comparison to age-matched WKY at prehypertensive (3 to 4 weeks), developing (7 to 8 weeks), and established (12 to 13 weeks) stages of hypertension. AT1A receptor mRNA was mainly expressed in the hypothalamus and adrenal gland. AT1B receptor mRNA was detected in the pituitary and adrenal gland. AT2 receptor mRNA was prominent only in the adrenal gland. When compared with WKY, SHR showed increased AT1A receptor mRNA levels in the pituitary gland at all ages in contrast to reduced pituitary AT1B receptor mRNA levels. In the adrenal gland of SHR, AT1B receptor mRNA levels were decreased at the hypertensive stages when compared with WKY. The reduced expression of adrenal AT1B receptor mRNA was localized selectively in the zona glomerulosa by in situ hybridization. No differences were observed between WKY and SHR in the expression of hypothalamic ANG receptors. ANG significantly increased plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone in dexamethasone-treated SHR but not in WKY. The aldosterone response to ANG was similar in SHR and WKY. Our results suggest a differential gene expression of AT1A and AT1B receptors in the hypothalamo-pituitary-adrenal axis of SHR and normotensive WKY and imply the participation of AT1 receptors in an exaggerated endocrine stress response of SHR to ANG.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
984-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12642505-Adrenal Glands, pubmed-meshheading:12642505-Angiotensins, pubmed-meshheading:12642505-Animals, pubmed-meshheading:12642505-Dexamethasone, pubmed-meshheading:12642505-Hormones, pubmed-meshheading:12642505-Hypertension, pubmed-meshheading:12642505-Hypothalamus, pubmed-meshheading:12642505-In Situ Hybridization, pubmed-meshheading:12642505-Male, pubmed-meshheading:12642505-Organ Specificity, pubmed-meshheading:12642505-Pituitary Gland, pubmed-meshheading:12642505-Protein Isoforms, pubmed-meshheading:12642505-RNA, Messenger, pubmed-meshheading:12642505-Rats, pubmed-meshheading:12642505-Rats, Inbred SHR, pubmed-meshheading:12642505-Rats, Inbred WKY, pubmed-meshheading:12642505-Receptor, Angiotensin, Type 1, pubmed-meshheading:12642505-Receptors, Angiotensin, pubmed-meshheading:12642505-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12642505-Transcription, Genetic
pubmed:year
2003
pubmed:articleTitle
Differential expression of AT1 receptors in the pituitary and adrenal gland of SHR and WKY.
pubmed:affiliation
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. Joehren@medinf.mu-luebeck.de
pubmed:publicationType
Journal Article, Comparative Study