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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5553
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pubmed:dateCreated |
1976-7-6
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pubmed:abstractText |
Computer simulation of the molecular dynamics of retinal during its photoisomerisation inside a restrictive active site gives a detailed model for the sequence of events in the first step of the vision process. It is proposed that the prelumirhodopsin intermediate contains a strained all-trans retinal molecule produced directly and rapidly from the 11-cis, 12-s-trans conformation in rhodopsin by a bicycle-pedal isomerisation. The model reproduces the main experimental observations and explains how the protein makes the photoisomerisation path unique.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
260
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
679-83
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pubmed:dateRevised |
2009-10-27
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pubmed:meshHeading |
pubmed-meshheading:1264239-Binding Sites,
pubmed-meshheading:1264239-Chemical Phenomena,
pubmed-meshheading:1264239-Chemistry,
pubmed-meshheading:1264239-Models, Biological,
pubmed-meshheading:1264239-Molecular Conformation,
pubmed-meshheading:1264239-Photochemistry,
pubmed-meshheading:1264239-Protein Conformation,
pubmed-meshheading:1264239-Retinal Pigments,
pubmed-meshheading:1264239-Retinaldehyde,
pubmed-meshheading:1264239-Rhodopsin,
pubmed-meshheading:1264239-Scattering, Radiation,
pubmed-meshheading:1264239-Schiff Bases,
pubmed-meshheading:1264239-Spectrum Analysis,
pubmed-meshheading:1264239-Stereoisomerism,
pubmed-meshheading:1264239-Vision, Ocular,
pubmed-meshheading:1264239-Vitamin A
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pubmed:year |
1976
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pubmed:articleTitle |
Bicycle-pedal model for the first step in the vision process.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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