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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-17
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pubmed:abstractText |
Changes in the biological efficacy of leptin were evaluated in obesity-resistant (A/J) and obesity-prone (C57BL/6J) mice at weaning and after consuming a high-fat (HF) diet for 4 and 8 wk. There was no evidence of leptin resistance in either strain at the start of the study, but after 4 and 8 wk on the HF diet, C57BL/6J mice became unresponsive to ip leptin. C57BL/6J mice responded to intracerebroventricular leptin at these time points but developed peripheral resistance to sympathetic stimulation of retroperitoneal white adipose tissue. In contrast, intracerebroventricular leptin was fully effective in A/J mice, reproducing the complete profile of responses observed in weanling mice. A/J mice were also partially responsive to ip leptin at both time points, increasing uncoupling protein 1 mRNA expression in brown adipose tissue and decreasing leptin mRNA in white adipose tissue. The findings indicate that retention of leptin responsiveness is an important component of the ability of A/J mice to mount a robust adaptive thermogenic response and resist diet-induced obesity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1155-63
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12639896-Adipose Tissue,
pubmed-meshheading:12639896-Animals,
pubmed-meshheading:12639896-Carrier Proteins,
pubmed-meshheading:12639896-DNA-Binding Proteins,
pubmed-meshheading:12639896-Dietary Fats,
pubmed-meshheading:12639896-Energy Intake,
pubmed-meshheading:12639896-Gene Expression,
pubmed-meshheading:12639896-Hypothalamus,
pubmed-meshheading:12639896-Ion Channels,
pubmed-meshheading:12639896-Leptin,
pubmed-meshheading:12639896-Membrane Proteins,
pubmed-meshheading:12639896-Mice,
pubmed-meshheading:12639896-Mice, Inbred A,
pubmed-meshheading:12639896-Mice, Inbred C57BL,
pubmed-meshheading:12639896-Mitochondrial Proteins,
pubmed-meshheading:12639896-Obesity,
pubmed-meshheading:12639896-STAT3 Transcription Factor,
pubmed-meshheading:12639896-Species Specificity,
pubmed-meshheading:12639896-Trans-Activators
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pubmed:year |
2003
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pubmed:articleTitle |
Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity.
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pubmed:affiliation |
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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