Source:http://linkedlifedata.com/resource/pubmed/id/12639741
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
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| pubmed:dateCreated |
2003-3-17
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| pubmed:abstractText |
The hypoglycaemic and hypolipidemic effect of ethanolic extract obtained from seeds of E. jambolana was investigated in alloxan-induced diabetic rabbits. Hypoglycaemic activity was assessed by reduction in fasting blood glucose (FBG) at 90min and also fall in peak blood glucose during glucose tolerance test (GTT) in sub-diabetic and mild diabetic (MD) rabbits, but in severe diabetic (SD) rabbits by reduction in FBG at 90min. Ethanolic extract (100mg/kg body weight) when given orally to sub-diabetic (AR) for 1 day, MD for 7 days and SD for 15 days showed significant fall in FBG at 90min (12% AR, 18.9% MD and 29% SD) and also produced 16.9% fall in peak blood glucose in AR and 21% in MD rabbits during GTT. When administered daily for 15 days to MD and SD rabbits, significant fall in FBG (41.3% MD, 31.6% SD) and glycosylated haemoglobin (GHb) levels (23.3% MD, 26.6% SD) were observed, while serum insulin level showed significant increase (32.8% MD, 26.9% SD). Liver and muscle glycogen content also increased. The ethanolic extract of seeds also exhibited significant hypolipidemic effect as evident from fall in total serum cholesterol (TC)/high density lipoprotein cholesterol (HDL-c) ratio, serum low density lipoprotein cholesterol (LDL-c) levels and decreased activity of HMG-CoA reductase. The histopathological studies of liver, pancreas and aorta in alcoholic extract treated diabetic groups revealed almost normal appearance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Hypolipidemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Liver Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0378-8741
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
201-6
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12639741-Animals,
pubmed-meshheading:12639741-Blood Glucose,
pubmed-meshheading:12639741-Diabetes Mellitus, Experimental,
pubmed-meshheading:12639741-Eugenia,
pubmed-meshheading:12639741-Glucose Tolerance Test,
pubmed-meshheading:12639741-Hemoglobin A, Glycosylated,
pubmed-meshheading:12639741-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:12639741-Hypoglycemic Agents,
pubmed-meshheading:12639741-Hypolipidemic Agents,
pubmed-meshheading:12639741-India,
pubmed-meshheading:12639741-Insulin,
pubmed-meshheading:12639741-Lipids,
pubmed-meshheading:12639741-Liver,
pubmed-meshheading:12639741-Liver Glycogen,
pubmed-meshheading:12639741-Male,
pubmed-meshheading:12639741-Muscle, Skeletal,
pubmed-meshheading:12639741-Phytotherapy,
pubmed-meshheading:12639741-Plant Extracts,
pubmed-meshheading:12639741-Plants, Medicinal,
pubmed-meshheading:12639741-Rabbits,
pubmed-meshheading:12639741-Seeds
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| pubmed:year |
2003
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| pubmed:articleTitle |
Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits.
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| pubmed:affiliation |
Department of Biochemistry, University College of Medical Sciences and GTB Hospital, Delhi 110095, India. Sharmasbs@rediff.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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