| pubmed-article:12639576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C1318700 | lld:lifeskim |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:12639576 | lifeskim:mentions | umls-concept:C0005197 | lld:lifeskim |
| pubmed-article:12639576 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12639576 | pubmed:dateCreated | 2003-3-17 | lld:pubmed |
| pubmed-article:12639576 | pubmed:abstractText | A series of N(2)-furoyl and N(2)pyrimidinyl beta-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number of target compounds in a rapid fashion. Representative compounds exhibit superior selectivity to sildenafil versus other isozymes of PDEs, and demonstrated in vivo efficacy in increasing introcavernosal pressure in dogs. | lld:pubmed |
| pubmed-article:12639576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12639576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12639576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12639576 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12639576 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:JiangWeiqinW | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:QiuYuhongY | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:KraftPatricia... | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:Haynes-Johnso... | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:CraigElizabet... | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:SuiZhihuaZ | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:GuanJihuaJ | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:MacielagMark... | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:Bhattacharjee... | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:JohnT... | lld:pubmed |
| pubmed-article:12639576 | pubmed:author | pubmed-author:ClancyJoannaJ | lld:pubmed |
| pubmed-article:12639576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12639576 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:12639576 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12639576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12639576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12639576 | pubmed:pagination | 761-5 | lld:pubmed |
| pubmed-article:12639576 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
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| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
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| pubmed-article:12639576 | pubmed:meshHeading | pubmed-meshheading:12639576... | lld:pubmed |
| pubmed-article:12639576 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12639576 | pubmed:articleTitle | Synthesis and biological activities of novel beta-carbolines as PDE5 inhibitors. | lld:pubmed |
| pubmed-article:12639576 | pubmed:affiliation | Johnson & Johnson Pharmaceutical Research & Development L.L.C., 1000 Route 202, Raritan, NJ 08869, USA. zsui@prius.jnj.com | lld:pubmed |
| pubmed-article:12639576 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12639576 | lld:chembl |
