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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-17
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pubmed:abstractText |
A series of N(2)-furoyl and N(2)pyrimidinyl beta-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number of target compounds in a rapid fashion. Representative compounds exhibit superior selectivity to sildenafil versus other isozymes of PDEs, and demonstrated in vivo efficacy in increasing introcavernosal pressure in dogs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-GMP Phosphodiesterases,
http://linkedlifedata.com/resource/pubmed/chemical/Carbolines,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/PDE5A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/sildenafil
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BhattacharjeeSheelaS,
pubmed-author:ClancyJoannaJ,
pubmed-author:CraigElizabethE,
pubmed-author:GuanJihuaJ,
pubmed-author:Haynes-JohnsonDonnaD,
pubmed-author:JiangWeiqinW,
pubmed-author:JohnT MatthewTM,
pubmed-author:KraftPatriciaP,
pubmed-author:MacielagMark JMJ,
pubmed-author:QiuYuhongY,
pubmed-author:SuiZhihuaZ
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
761-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12639576-3',5'-Cyclic-GMP Phosphodiesterases,
pubmed-meshheading:12639576-Animals,
pubmed-meshheading:12639576-Blood Pressure,
pubmed-meshheading:12639576-Carbolines,
pubmed-meshheading:12639576-Combinatorial Chemistry Techniques,
pubmed-meshheading:12639576-Cyclic Nucleotide Phosphodiesterases, Type 5,
pubmed-meshheading:12639576-Dogs,
pubmed-meshheading:12639576-Drug Evaluation, Preclinical,
pubmed-meshheading:12639576-Erectile Dysfunction,
pubmed-meshheading:12639576-Humans,
pubmed-meshheading:12639576-Isoenzymes,
pubmed-meshheading:12639576-Male,
pubmed-meshheading:12639576-Penis,
pubmed-meshheading:12639576-Piperazines,
pubmed-meshheading:12639576-Purines,
pubmed-meshheading:12639576-Solubility,
pubmed-meshheading:12639576-Structure-Activity Relationship,
pubmed-meshheading:12639576-Sulfones
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and biological activities of novel beta-carbolines as PDE5 inhibitors.
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pubmed:affiliation |
Johnson & Johnson Pharmaceutical Research & Development L.L.C., 1000 Route 202, Raritan, NJ 08869, USA. zsui@prius.jnj.com
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pubmed:publicationType |
Journal Article
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