Source:http://linkedlifedata.com/resource/pubmed/id/12639484
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001483,
umls-concept:C0012854,
umls-concept:C0017262,
umls-concept:C0019196,
umls-concept:C0026809,
umls-concept:C0032136,
umls-concept:C0039195,
umls-concept:C0042196,
umls-concept:C0123759,
umls-concept:C0185117,
umls-concept:C0205195,
umls-concept:C0205263,
umls-concept:C0332283,
umls-concept:C2349975,
umls-concept:C2911684
|
| pubmed:issue |
15
|
| pubmed:dateCreated |
2003-3-17
|
| pubmed:abstractText |
We evaluated the prime-boost immunization consisting of hepatitis C virus (HCV)-core expression plasmid (pCEP4-core) and replication-defective adenovirus expressing HCV-core (Adex1SR3ST) for core-specific CTL induction in mice. Compared to a single booster, double boosters after priming enhance CTL induction. The prime-double boosts immunization involving pCEP4-core priming followed by pCEP4-core and Adex1SR3ST boostings (pC/pC/aC) can induce core-specific CTLs as well as other combinations: pC/aC/aC; aC/pC/pC; aC/aC/aC, whereas pC/pC/pC does not induce CTLs. Furthermore, co-administration of interleukin-12 (IL-12) expression plasmid leads to the highly efficient CTL induction and clearance of HCV-core expressing vaccinia virus challenged. Thus, the prime-double boosts immunization together with IL-12 may be promising for HCV vaccine.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0264-410X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
2
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1629-39
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12639484-Adenoviridae,
pubmed-meshheading:12639484-Animals,
pubmed-meshheading:12639484-Cell Line,
pubmed-meshheading:12639484-Cercopithecus aethiops,
pubmed-meshheading:12639484-Drug Therapy, Combination,
pubmed-meshheading:12639484-Epitopes, T-Lymphocyte,
pubmed-meshheading:12639484-Female,
pubmed-meshheading:12639484-Gene Expression Regulation,
pubmed-meshheading:12639484-Hepacivirus,
pubmed-meshheading:12639484-Humans,
pubmed-meshheading:12639484-Immunization, Secondary,
pubmed-meshheading:12639484-Interleukin-12,
pubmed-meshheading:12639484-Mice,
pubmed-meshheading:12639484-Mice, Inbred BALB C,
pubmed-meshheading:12639484-Plasmids,
pubmed-meshheading:12639484-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12639484-Tumor Cells, Cultured,
pubmed-meshheading:12639484-Vaccines, DNA
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Enhanced induction of hepatitis C virus-specific cytotoxic T lymphocytes and protective efficacy in mice by DNA vaccination followed by adenovirus boosting in combination with the interleukin-12 expression plasmid.
|
| pubmed:affiliation |
Department of Microbiology, Saitama Medical School, Moroyama-Cho, Iruma-Gun, 350-0495, Saitama, Japan. matsui@saitama-med.ac.jp
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|