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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-3-17
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pubmed:abstractText |
Stimulation and proliferation of lymphocytes require activation of Ras. S-farnesylthiosalicylic acid (FTS) is a synthetic substance that detaches Ras from the inner cell membrane and induces its rapid degradation. Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies detected in patients with antiphospholipid syndrome (APS), which is associated with thrombosis, pregnancy losses, and thrombocytopenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antiphospholipid,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Farnesol,
http://linkedlifedata.com/resource/pubmed/chemical/Freund's Adjuvant,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Glycoprotein I,
http://linkedlifedata.com/resource/pubmed/chemical/farnesylthiosalicylic acid,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
0171-2985
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
207
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12638903-Animals,
pubmed-meshheading:12638903-Antibodies, Antiphospholipid,
pubmed-meshheading:12638903-Antiphospholipid Syndrome,
pubmed-meshheading:12638903-Autoantibodies,
pubmed-meshheading:12638903-Disease Models, Animal,
pubmed-meshheading:12638903-Enzyme Inhibitors,
pubmed-meshheading:12638903-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12638903-Farnesol,
pubmed-meshheading:12638903-Female,
pubmed-meshheading:12638903-Freund's Adjuvant,
pubmed-meshheading:12638903-Glycoproteins,
pubmed-meshheading:12638903-Mice,
pubmed-meshheading:12638903-Mice, Inbred BALB C,
pubmed-meshheading:12638903-Mice, Inbred MRL lpr,
pubmed-meshheading:12638903-Salicylic Acids,
pubmed-meshheading:12638903-Time Factors,
pubmed-meshheading:12638903-beta 2-Glycoprotein I,
pubmed-meshheading:12638903-ras Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome.
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pubmed:affiliation |
Dept. of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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