|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2003-3-14
|
|
pubmed:abstractText |
To assess the safety and toxicity profile of escalating doses of intravenous irinotecan, in combination with a fixed dose of oral ciclosporin (Cs) and to determine the pharmacokinetic profile of irinotecan and its metabolites.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0732-183X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1125-32
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12637480-Administration, Oral,
pubmed-meshheading:12637480-Adult,
pubmed-meshheading:12637480-Aged,
pubmed-meshheading:12637480-Antimetabolites, Antineoplastic,
pubmed-meshheading:12637480-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12637480-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:12637480-Camptothecin,
pubmed-meshheading:12637480-Colonic Neoplasms,
pubmed-meshheading:12637480-Cyclosporine,
pubmed-meshheading:12637480-Drug Resistance, Neoplasm,
pubmed-meshheading:12637480-Female,
pubmed-meshheading:12637480-Fluorouracil,
pubmed-meshheading:12637480-Humans,
pubmed-meshheading:12637480-Infusions, Intravenous,
pubmed-meshheading:12637480-Male,
pubmed-meshheading:12637480-Middle Aged,
pubmed-meshheading:12637480-Neoplasm Staging,
pubmed-meshheading:12637480-Treatment Outcome
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Phase I and pharmacokinetic study of intravenous irinotecan plus oral ciclosporin in patients with fuorouracil-refractory metastatic colon cancer.
|
|
pubmed:affiliation |
Cancer Research UK Clinical Centre at Leeds, Cookridge Hospital, Leeds LS16 6QB, United Kingdom.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
|
