Source:http://linkedlifedata.com/resource/pubmed/id/12635741
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001613,
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umls-concept:C0547043,
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umls-concept:C1549078,
umls-concept:C1997894,
umls-concept:C2603343,
umls-concept:C2732140
|
| pubmed:issue |
4
|
| pubmed:dateCreated |
2003-3-14
|
| pubmed:abstractText |
Neural and stem cell transplantation is emerging as a potential treatment for neurodegenerative diseases from Parkinson's to Huntington's disease. Stereotactic placement of dopaminergic neurons in the caudate-putamen (striatum), is being attempted in centers of excellence and has proved to be beneficial. Basic research using cell transplantation indicates that structural development mechanisms seen in immature brains, i.e., fetal brains, can also function in the adult brain. The adult brain consumes 15% of the resting cardiac output for its metabolic needs. While most human tissues can sustain an anaerobic assault for a few minutes up to 30 minutes, a sudden total lack of oxygen supply to the brain cells in an adult will render the person unconscious within five to ten seconds. Our team has been working on the problem of human fetal tissue response to antigenic assault for the last two decades. In the present series, 12 patients with prolonged histories of Parkinsonism, who were not responding to anti-Parkinsonian drugs, and could not afford costly stereotactic surgery or deep brain stimulation and other modalities of recent Parkinson's disease treatment, were enrolled in the study.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0390-6663
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
259-66
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12635741-Aged,
pubmed-meshheading:12635741-Brain Tissue Transplantation,
pubmed-meshheading:12635741-Female,
pubmed-meshheading:12635741-Fetal Tissue Transplantation,
pubmed-meshheading:12635741-Humans,
pubmed-meshheading:12635741-Male,
pubmed-meshheading:12635741-Mesencephalon,
pubmed-meshheading:12635741-Middle Aged,
pubmed-meshheading:12635741-Parkinson Disease
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Can human fetal cortical brain tissue transplant (up to 20 weeks) sustain its metabolic and oxygen requirements in a heterotopic site outside the brain? A study of 12 volunteers with Parkinson's disease.
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| pubmed:affiliation |
Bijoygarh State Hospital, Calcutta, India.
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| pubmed:publicationType |
Journal Article
|