12631620

Source:http://linkedlifedata.com/resource/pubmed/id/12631620

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007131, umls-concept:C0007600, umls-concept:C0026255, umls-concept:C0086418, umls-concept:C0162638, umls-concept:C0237477, umls-concept:C0334227, umls-concept:C0441712, umls-concept:C1443643
pubmed:issue	3
pubmed:dateCreated	2003-3-12
pubmed:abstractText	PS-341 is a novel dipeptide boronic acid proteasome inhibitor with in vitro and in vivo antitumor activity that induces mechanisms of apoptosis by unknown mechanisms.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA 50270, http://linkedlifedata.com/resource/pubmed/grant/U01 CA 76642
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Boronic Acids, http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclins, http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes, http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/bortezomib
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1078-0432
pubmed:author	pubmed-author:AdamsJulianJ, pubmed-author:ElliottPeter JPJ, pubmed-author:HollandJames FJF, pubmed-author:JiangJian-DongJD, pubmed-author:LiebesLeonardL, pubmed-author:LingYi-HeYH, pubmed-author:MuggiaFranco MFM, pubmed-author:Perez-SolerRomanR
pubmed:issnType	Print
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1145-54
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:12631620-Apoptosis, pubmed-meshheading:12631620-Blotting, Western, pubmed-meshheading:12631620-Boronic Acids, pubmed-meshheading:12631620-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:12631620-Cell Cycle, pubmed-meshheading:12631620-Cell Division, pubmed-meshheading:12631620-Cyclin-Dependent Kinase Inhibitor p21, pubmed-meshheading:12631620-Cyclins, pubmed-meshheading:12631620-Cysteine Endopeptidases, pubmed-meshheading:12631620-Dose-Response Relationship, Drug, pubmed-meshheading:12631620-G2 Phase, pubmed-meshheading:12631620-Humans, pubmed-meshheading:12631620-Immunohistochemistry, pubmed-meshheading:12631620-Lung Neoplasms, pubmed-meshheading:12631620-Microtubules, pubmed-meshheading:12631620-Mitosis, pubmed-meshheading:12631620-Multienzyme Complexes, pubmed-meshheading:12631620-Mutation, pubmed-meshheading:12631620-Precipitin Tests, pubmed-meshheading:12631620-Protease Inhibitors, pubmed-meshheading:12631620-Proteasome Endopeptidase Complex, pubmed-meshheading:12631620-Pyrazines, pubmed-meshheading:12631620-Time Factors, pubmed-meshheading:12631620-Tumor Cells, Cultured, pubmed-meshheading:12631620-Tumor Suppressor Protein p53, pubmed-meshheading:12631620-Up-Regulation
pubmed:year	2003
pubmed:articleTitle	Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines.
pubmed:affiliation	Department of Oncology, Albert Einstein College of Medicine, 13200 Morris Park Avenue, Bronx, NY 10461, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S.