| pubmed-article:12631373 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C0538727 | lld:lifeskim |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C0005823 | lld:lifeskim |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C0449468 | lld:lifeskim |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:12631373 | lifeskim:mentions | umls-concept:C0549193 | lld:lifeskim |
| pubmed-article:12631373 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12631373 | pubmed:dateCreated | 2003-3-12 | lld:pubmed |
| pubmed-article:12631373 | pubmed:abstractText | Overhydration is a risk factor for hypertension and left ventricular hypertrophy in peritoneal dialysis patients. Recently, a high prevalence of subclinical overhydration was observed in peritoneal dialysis patients. Aim of the present open-label randomized study was to assess the effect of a icodextrin 7.5% solution on fluid status [extracellular water (ECW) bromide dilution], blood pressure regulation (24-hour ambulatory measurements) and echocardiographic parameters during a study period of 4 months, and to relate the effect to peritoneal membrane characteristics (dialysate/plasma creatinine ratio). Forty peritoneal dialysis patients (22 treated with icodextrin, 18 controls) were randomized to either treatment with icodextrin during the long dwell or standard glucose solutions. Thirty-two patients (19 treated with icodextrin, 13 controls] completed the study. The use of icodextrin resulted in a significant increase in daily ultrafiltration volume (744 +/- 767 mL vs. 1670 +/- 1038 mL; P = 0.012) and a decrease in ECW (17.5 +/- 5.2 L vs. 15.8 +/- 3.8 L; P = 0.035). Also the change in ECW between controls and patients treated with icodextrin was significant (-1.7 +/- 3.3 L vs. +0.9 +/- 2.2 L; P = 0.013). The effect of icodextrin on ECW was not related to peritoneal membrane characteristics, but significantly related to the fluid state of the patients (ECW:height) (r = -0.72; P < 0.0001). Left ventricular mass (LVM) decreased significantly in the icodextrin-treated group (241 +/- 53 grams vs. 228 +/- 42 grams; P = 0.03), but not in the control group. In this randomized open-label study, the use of icodextrin resulted in a significant reduction in ECW and LVM. The effect of icodextrin on ECW was not related to peritoneal membrane characteristics, but was related to the initial fluid state of the patient. | lld:pubmed |
| pubmed-article:12631373 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12631373 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12631373 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12631373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12631373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12631373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12631373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12631373 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12631373 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12631373 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:HeybergerSS | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:KoomanJeroen... | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:LeunissenKare... | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:KoningsConsta... | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:SchonckMarcM | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:GerlagPaul... | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:WirtzJorisJ | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:HoorntjeSteve... | lld:pubmed |
| pubmed-article:12631373 | pubmed:author | pubmed-author:WoltersJohann... | lld:pubmed |
| pubmed-article:12631373 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12631373 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:12631373 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12631373 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12631373 | pubmed:pagination | 1556-63 | lld:pubmed |
| pubmed-article:12631373 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12631373 | pubmed:meshHeading | pubmed-meshheading:12631373... | lld:pubmed |
| pubmed-article:12631373 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12631373 | pubmed:articleTitle | Effect of icodextrin on volume status, blood pressure and echocardiographic parameters: a randomized study. | lld:pubmed |
| pubmed-article:12631373 | pubmed:affiliation | Department of Internal Medicine, University Hospital Maastricht, The Netherlands. | lld:pubmed |
| pubmed-article:12631373 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12631373 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12631373 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:12631373 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:12631373 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12631373 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12631373 | lld:pubmed |
