Source:http://linkedlifedata.com/resource/pubmed/id/12631373
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2003-3-12
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| pubmed:abstractText |
Overhydration is a risk factor for hypertension and left ventricular hypertrophy in peritoneal dialysis patients. Recently, a high prevalence of subclinical overhydration was observed in peritoneal dialysis patients. Aim of the present open-label randomized study was to assess the effect of a icodextrin 7.5% solution on fluid status [extracellular water (ECW) bromide dilution], blood pressure regulation (24-hour ambulatory measurements) and echocardiographic parameters during a study period of 4 months, and to relate the effect to peritoneal membrane characteristics (dialysate/plasma creatinine ratio). Forty peritoneal dialysis patients (22 treated with icodextrin, 18 controls) were randomized to either treatment with icodextrin during the long dwell or standard glucose solutions. Thirty-two patients (19 treated with icodextrin, 13 controls] completed the study. The use of icodextrin resulted in a significant increase in daily ultrafiltration volume (744 +/- 767 mL vs. 1670 +/- 1038 mL; P = 0.012) and a decrease in ECW (17.5 +/- 5.2 L vs. 15.8 +/- 3.8 L; P = 0.035). Also the change in ECW between controls and patients treated with icodextrin was significant (-1.7 +/- 3.3 L vs. +0.9 +/- 2.2 L; P = 0.013). The effect of icodextrin on ECW was not related to peritoneal membrane characteristics, but significantly related to the fluid state of the patients (ECW:height) (r = -0.72; P < 0.0001). Left ventricular mass (LVM) decreased significantly in the icodextrin-treated group (241 +/- 53 grams vs. 228 +/- 42 grams; P = 0.03), but not in the control group. In this randomized open-label study, the use of icodextrin resulted in a significant reduction in ECW and LVM. The effect of icodextrin on ECW was not related to peritoneal membrane characteristics, but was related to the initial fluid state of the patient.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0085-2538
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| pubmed:author |
pubmed-author:GerlagPaul GPG,
pubmed-author:HeybergerSS,
pubmed-author:HoorntjeSteven JSJ,
pubmed-author:KoningsConstantijn J A MCJ,
pubmed-author:KoomanJeroen PJP,
pubmed-author:LeunissenKarel M LKM,
pubmed-author:SchonckMarcM,
pubmed-author:WirtzJorisJ,
pubmed-author:WoltersJohannesJ,
pubmed-author:van den Wall BakeA WarmoldAW,
pubmed-author:van der SandeFrank MFM
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| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1556-63
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12631373-Adult,
pubmed-meshheading:12631373-Aged,
pubmed-meshheading:12631373-Blood Pressure,
pubmed-meshheading:12631373-Blood Volume,
pubmed-meshheading:12631373-Body Composition,
pubmed-meshheading:12631373-Body Weight,
pubmed-meshheading:12631373-Dialysis Solutions,
pubmed-meshheading:12631373-Diuresis,
pubmed-meshheading:12631373-Echocardiography,
pubmed-meshheading:12631373-Female,
pubmed-meshheading:12631373-Glomerular Filtration Rate,
pubmed-meshheading:12631373-Glucans,
pubmed-meshheading:12631373-Glucose,
pubmed-meshheading:12631373-Humans,
pubmed-meshheading:12631373-Kidney Failure, Chronic,
pubmed-meshheading:12631373-Male,
pubmed-meshheading:12631373-Middle Aged,
pubmed-meshheading:12631373-Peritoneal Dialysis,
pubmed-meshheading:12631373-Peritoneum,
pubmed-meshheading:12631373-Water-Electrolyte Balance
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Effect of icodextrin on volume status, blood pressure and echocardiographic parameters: a randomized study.
|
| pubmed:affiliation |
Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|