Bladder outlet obstruction leads to histological and functional changes in the bladder over time. We investigated the role of inducible nitric oxide synthase (iNOS) in the progression of pathological changes of the bladder secondary to outlet obstruction in a rat and a mouse model.
Center for Pediatric Urology, Department of Urology, Children's Hospital of New York-Weill Medical College of Cornell University, New York, New York, USA.