Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-3-11
pubmed:abstractText
The repression of the maternally inherited Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR). Here we document that point mutations of the nucleotides in physical contact with CTCF within the endogenous H19 ICR lead to loss of CTCF binding and Igf2 imprinting only when passaged through the female germline. This effect is accompanied by a significant loss of methylation protection of the maternally derived H19 ICR. Because CTCF interacts with other imprinting control regions, it emerges as a central factor responsible for interpreting and propagating gamete-derived epigenetic marks and for organizing epigenetically controlled expression domains.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-10579938, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-10801414, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-10837224, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-10839546, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-10839547, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-10899010, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-10921905, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-11101841, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-11128572, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-11228144, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-11509237, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-11525835, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-11971967, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-12011441, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-12029086, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-8378314, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-8575319, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-8614834, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-9016686, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-9234689, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-9294195, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-9326948, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-9354788, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-9442905, http://linkedlifedata.com/resource/pubmed/commentcorrection/12629040-9584126
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
586-90
pubmed:dateRevised
2011-10-7
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains.
pubmed:affiliation
Department of Development & Genetics, Evolution Biology Centre, Uppsala University, S-752 36 Uppsala, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't