Linked Life Data

12628518

Source:http://linkedlifedata.com/resource/pubmed/id/12628518

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-3-11
pubmed:abstractText
Consumption of tea (Camellia sinensis) has been associated with many health benefits including the prevention of cancer. Based on in vitro experiments, many mechanisms have been proposed to account for the cancer chemopreventive activity. The importance of some of these mechanisms in vivo remains in question due to an incomplete understanding of the bioavailability of the polyphenolic compounds in tea. In this article, the literature on the cancer chemopreventive activity of tea and the tea polyphenols is discussed as well as some of the possible mechanisms for this activity. Whereas studies in animal models and with cell lines have demonstrated cancer preventive activity, the epidemiological data remain mixed. This discrepancy may arise from several factors including lifestyle, correlation between animal models and humans, and differences in metabolism among individuals. Results on the bioavailability and biotransformation of the tea polyphenols help explain some of the differences. We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability and cancer chemoprevention.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0027-5107
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:volume
523-524
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Cancer chemopreventive activity and bioavailability of tea and tea polyphenols.
pubmed:affiliation
Department of Chemical Biology, Laboratory for Cancer Research, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA.
pubmed:publicationType
Journal Article, Review