Linked Life Data

12628459

Source:http://linkedlifedata.com/resource/pubmed/id/12628459

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pubmed-article:12628459pubmed:dateCreated2003-3-11lld:pubmed
pubmed-article:12628459pubmed:abstractTextAcetylcholine (ACh), synthesized in mammalian non-neuronal cells such as epithelial cells of the airways, digestive tract and skin, is involved in the regulation of basic cell functions (so-called non-neuronal cholinergic system). In the present experiments rat trachea epithelial cells have been cultured to study the proliferative effect of applied ACh by [3H]thymidine incorporation. ACh (exposure time 24 h) caused a concentration-dependent increase in cell proliferation with a doubling of the [3H]thymidine incorporation at a concentration of 0.1 microM. This effect was partly reduced by 30 microM tubocurarine and completely abolished by the additional application of 1 microM atropine. The stimulatory effect of acetylcholine, remaining in the presence of tubocurarine, was prevented by 1 microM pirenzepine (preferentially acting at M1-receptors), but neither by 1 microM AFDX 116 (preferentially acting at M2-receptors) nor by 1 microM hexahydrosiladifenidol (preferentially acting at M3-receptors). The combination of tubocurarine and pirenzepine halved the basal [3H]thymidine incorporation. In conclusion, ACh produces a proliferative effect in rat trachea epithelial cells, the effect being mediated by both nicotinic receptors and muscarinic receptors of the M1-subtype.lld:pubmed
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pubmed-article:12628459pubmed:authorpubmed-author:WesslerIgnazIlld:pubmed
pubmed-article:12628459pubmed:authorpubmed-author:MetzenJürgenJlld:pubmed
pubmed-article:12628459pubmed:copyrightInfoCopyright 2003 Elsevier Science Inc.lld:pubmed
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pubmed-article:12628459pubmed:pagination2075-80lld:pubmed
pubmed-article:12628459pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12628459pubmed:year2003lld:pubmed
pubmed-article:12628459pubmed:articleTitleProliferative effect of acetylcholine on rat trachea epithelial cells is mediated by nicotinic receptors and muscarinic receptors of the M1-subtype.lld:pubmed
pubmed-article:12628459pubmed:affiliationInstitute of Pharmacology, University of Mainz, Obere Zahlbacher Str 67, D-55101, Mainz, Germany.lld:pubmed
pubmed-article:12628459pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12628459pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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