Source:http://linkedlifedata.com/resource/pubmed/id/12628278
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-3-11
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| pubmed:abstractText |
It has been suggested that gene aberrations may contribute to vascular endothelial dysfunction of pre-eclampsia in Caucasian and Japanese women. This study was undertaken to examine the association between pre-eclampsia in Black Zulu speaking South African women and the Factor 5 Leiden mutation. 100 patients with pre-eclampsia comprised the study group. The control group comprised 110 normotensive pregnant women of the same population group. Genotyping was performed to detect the G or A allele at residue 506 of the Factor V gene, and the C or T allele at residue 455 of the thrombomodulin gene. Our findings demonstrate that these particularly genetic loci are of little use in disease association studies for pre-eclampsia in homogenous Zulu speaking Africans.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1470-0328
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
110
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
327-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12628278-Adolescent,
pubmed-meshheading:12628278-Adult,
pubmed-meshheading:12628278-African Continental Ancestry Group,
pubmed-meshheading:12628278-Base Pair Mismatch,
pubmed-meshheading:12628278-Eclampsia,
pubmed-meshheading:12628278-Factor V,
pubmed-meshheading:12628278-Factor V Deficiency,
pubmed-meshheading:12628278-Female,
pubmed-meshheading:12628278-Gene Rearrangement,
pubmed-meshheading:12628278-Genotype,
pubmed-meshheading:12628278-Humans,
pubmed-meshheading:12628278-Mutation,
pubmed-meshheading:12628278-Polymerase Chain Reaction,
pubmed-meshheading:12628278-Pre-Eclampsia,
pubmed-meshheading:12628278-Pregnancy,
pubmed-meshheading:12628278-Prothrombin,
pubmed-meshheading:12628278-South Africa,
pubmed-meshheading:12628278-Thrombomodulin
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia.
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| pubmed:affiliation |
MRC/UN Pregnancy Hypertension Research Unit, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa.
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| pubmed:publicationType |
Journal Article
|