Linked Life Data

12628037

Source:http://linkedlifedata.com/resource/pubmed/id/12628037

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-3-11
pubmed:abstractText
The present study was designed to define how dietary fat type regulates body adiposity in dietary obesity-susceptible (DOS) Sprague-Dawley (SD) rats. Eighty-three SD rats received a purified diet containing 50 g maize oil (MO)/kg for 3 weeks and then thirty-nine of the rats, designated as the DOS rats, were allotted to diets containing 160 g MO (DOS-MO), beef tallow (DOS-BT) or fish oil (DOS-FO)/kg for 9 weeks. As a result of the experiment, the DOS-FO rats had significantly (P<0.05) reduced weight gain and abdominal and epididymal fat-pad mass than the DOS-MO and DOS-BT rats. Serum leptin level was also significantly (P<0.05) lower in the DOS-FO rats; however, hypothalamic leptin receptor (a and b) mRNA and neuropeptide Y expressions were not altered by dietary fat sources. A lower acetyl-CoA carboxylase mRNA expression in the liver was observed in the DOS-FO group, whereas hepatic peroxisome proliferator-activated receptor-gamma mRNA and protein expressions were markedly elevated in the DOS-FO group compared with those in the other groups. We did not observe differences in acetyl-CoA carboxylase and peroxisome proliferator-activated receptor-gamma expressions in epididymal fat of the DOS rats consuming MO, BT or FO. It is concluded from our present observations that dietary fat type, especially that rich in FO, plays a potential role in down-regulation of adiposity by altering hepatic lipogenic genes, rather than feeding behaviour, in the DOS-SD rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0007-1145
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
429-38
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12628037-Acetyl-CoA Carboxylase, pubmed-meshheading:12628037-Adipose Tissue, pubmed-meshheading:12628037-Animals, pubmed-meshheading:12628037-Cattle, pubmed-meshheading:12628037-Corn Oil, pubmed-meshheading:12628037-Dietary Fats, pubmed-meshheading:12628037-Disease Susceptibility, pubmed-meshheading:12628037-Eating, pubmed-meshheading:12628037-Fish Oils, pubmed-meshheading:12628037-Gene Expression Regulation, pubmed-meshheading:12628037-Leptin, pubmed-meshheading:12628037-Liver, pubmed-meshheading:12628037-Male, pubmed-meshheading:12628037-Neuropeptide Y, pubmed-meshheading:12628037-Obesity, pubmed-meshheading:12628037-Rats, pubmed-meshheading:12628037-Rats, Sprague-Dawley, pubmed-meshheading:12628037-Receptors, Cell Surface, pubmed-meshheading:12628037-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:12628037-Receptors, Leptin, pubmed-meshheading:12628037-Transcription Factors, pubmed-meshheading:12628037-Weight Gain
pubmed:year
2003
pubmed:articleTitle
Role of dietary fat type in the development of adiposity from dietary obesity-susceptible Sprague-Dawley rats.
pubmed:affiliation
Department of Animal Science & Biotechnology, RAIRC, Jinju National University, Chilam-Dong 150, Jinju, KyeongNam, Korea. isjang@jinju.ac.kr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't