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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-3-10
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pubmed:abstractText |
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays an important role in tumor growth and metastasis by regulating energy metabolism and inducing angiogenesis to survive cellular hypoxia. Increased levels of HIF-1alpha, the O(2)-regulated subunit of HIF-1, were noted during breast carcinogenesis. In this study, the prognostic value of HIF-1alpha expression and its correlation with various clinicopathologic variables in patients with invasive breast carcinoma were investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11246
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1573-81
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12627523-Adult,
pubmed-meshheading:12627523-Aged,
pubmed-meshheading:12627523-Aged, 80 and over,
pubmed-meshheading:12627523-Breast Neoplasms,
pubmed-meshheading:12627523-Carcinoma,
pubmed-meshheading:12627523-DNA-Binding Proteins,
pubmed-meshheading:12627523-Disease-Free Survival,
pubmed-meshheading:12627523-Female,
pubmed-meshheading:12627523-Follow-Up Studies,
pubmed-meshheading:12627523-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12627523-Helix-Loop-Helix Motifs,
pubmed-meshheading:12627523-Humans,
pubmed-meshheading:12627523-Hypoxia-Inducible Factor 1,
pubmed-meshheading:12627523-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:12627523-Immunohistochemistry,
pubmed-meshheading:12627523-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12627523-Lymphatic Metastasis,
pubmed-meshheading:12627523-Middle Aged,
pubmed-meshheading:12627523-Mitotic Index,
pubmed-meshheading:12627523-Nuclear Proteins,
pubmed-meshheading:12627523-Predictive Value of Tests,
pubmed-meshheading:12627523-Prognosis,
pubmed-meshheading:12627523-Receptor, erbB-2,
pubmed-meshheading:12627523-Receptors, Estrogen,
pubmed-meshheading:12627523-Receptors, Progesterone,
pubmed-meshheading:12627523-Transcription Factors,
pubmed-meshheading:12627523-Tumor Markers, Biological
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pubmed:year |
2003
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pubmed:articleTitle |
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma.
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pubmed:affiliation |
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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