Linked Life Data

12627520

Source:http://linkedlifedata.com/resource/pubmed/id/12627520

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-3-10
pubmed:abstractText
Carcinomas of the small intestine are rare, but the risk is greatly increased in patients with hereditary nonpolyposis colorectal cancer (HNPCC) due to an inherited mismatch repair (MMR) gene mutation, most commonly affecting the genes MLH1 or MSH2. Defective MMR is characterized by microsatellite instability (MSI) and loss of MMR protein expression in the tumor tissue. However, a subset of several sporadic tumor types, including about 15% of colon cancers, also evolve through defective MMR.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0008-543X
pubmed:author
pubmed:copyrightInfo
Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11197
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1551-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12627520-Adaptor Proteins, Signal Transducing, pubmed-meshheading:12627520-Adenocarcinoma, pubmed-meshheading:12627520-Adenosine Triphosphate, pubmed-meshheading:12627520-Adult, pubmed-meshheading:12627520-Age Factors, pubmed-meshheading:12627520-Age of Onset, pubmed-meshheading:12627520-Aged, pubmed-meshheading:12627520-Aged, 80 and over, pubmed-meshheading:12627520-Base Pair Mismatch, pubmed-meshheading:12627520-Carrier Proteins, pubmed-meshheading:12627520-DNA Repair, pubmed-meshheading:12627520-DNA-Binding Proteins, pubmed-meshheading:12627520-Female, pubmed-meshheading:12627520-Gene Expression Regulation, Neoplastic, pubmed-meshheading:12627520-Humans, pubmed-meshheading:12627520-Immunohistochemistry, pubmed-meshheading:12627520-Intestinal Neoplasms, pubmed-meshheading:12627520-Male, pubmed-meshheading:12627520-Microsatellite Repeats, pubmed-meshheading:12627520-Middle Aged, pubmed-meshheading:12627520-MutS Homolog 2 Protein, pubmed-meshheading:12627520-Neoplasm Proteins, pubmed-meshheading:12627520-Nuclear Proteins, pubmed-meshheading:12627520-Proto-Oncogene Proteins
pubmed:year
2003
pubmed:articleTitle
Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine.
pubmed:affiliation
Department of Oncology, University Hospital, Lund, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't