12627456

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0016733, umls-concept:C0036341, umls-concept:C0812223
pubmed:issue	1
pubmed:dateCreated	2003-3-10
pubmed:abstractText	NOTCH4 is a developmentally expressed gene recently reported to be in linkage disequilibrium (LD) with schizophrenia. We investigated this finding in our sample of subjects, focusing on an exonic (CTG)(n) polymorphism, examining not only the association of this polymorphism with the disease phenotype, but also its effect on frontal lobe brain morphology and cognitive function in both affected individuals and a psychiatrically normal comparison group. While we did not find any association or LD with schizophrenia, we identified striking effects of NOTCH4 variability on the trait measures. Within the respective schizophrenia and comparison groups, NOTCH4 allelic variability was correlated with differences in measures of frontal lobe cognitive performance and frontal lobe brain tissue volumes that were intuitively congruent. These within-group effects, however, were in opposite directions across groups. These findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/MH 00735, http://linkedlifedata.com/resource/pubmed/grant/MH 31593, http://linkedlifedata.com/resource/pubmed/grant/MH 40856, http://linkedlifedata.com/resource/pubmed/grant/MH 43212, http://linkedlifedata.com/resource/pubmed/grant/MH 43271
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101235742
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/NOTCH4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1552-4841
pubmed:author	pubmed-author:AndreasenNancy CNC, pubmed-author:CroweRaymond RRR, pubmed-author:NopoulosPeggyP, pubmed-author:PietilaJenniferJ, pubmed-author:WassinkThomas HTH
pubmed:copyrightInfo	Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	118B
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1-7
pubmed:dateRevised	2008-5-21
pubmed:meshHeading	pubmed-meshheading:12627456-Adult, pubmed-meshheading:12627456-Alleles, pubmed-meshheading:12627456-Analysis of Variance, pubmed-meshheading:12627456-DNA, pubmed-meshheading:12627456-Female, pubmed-meshheading:12627456-Frontal Lobe, pubmed-meshheading:12627456-Gene Frequency, pubmed-meshheading:12627456-Humans, pubmed-meshheading:12627456-Linkage Disequilibrium, pubmed-meshheading:12627456-Male, pubmed-meshheading:12627456-Neuropsychological Tests, pubmed-meshheading:12627456-Polymorphism, Genetic, pubmed-meshheading:12627456-Proto-Oncogene Proteins, pubmed-meshheading:12627456-Receptors, Cell Surface, pubmed-meshheading:12627456-Receptors, Notch, pubmed-meshheading:12627456-Schizophrenia, pubmed-meshheading:12627456-Schizophrenic Psychology, pubmed-meshheading:12627456-Trinucleotide Repeats
pubmed:year	2003
pubmed:articleTitle	NOTCH4 and the frontal lobe in schizophrenia.
pubmed:affiliation	Department of Psychiatry, Psychiatry Research/MEB, University of Iowa College of Medicine, Iowa City, IA 52242, USA. thomas-wassink@uiowa.edu.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't