Source:http://linkedlifedata.com/resource/pubmed/id/12626894
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-3-10
|
| pubmed:abstractText |
Clinical and laboratory findings were examined for 111 human T-cell lymphotropic virus type I (HTLV-I)-infected blood donors. HTLV-I provirus loads in subjects with a family history of adult T-cell leukemia (ATL) or HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) tended to be higher than those in subjects without a family history of these conditions. There were 3 asymptomatic patients with ATL, 4 with a history of uveitis, 7 with hyperreflexia in the lower limbs, and 3 with urinary frequency in the night. The mean CD4 cell/CD8 cell ratio +/- SD was significantly lower (p<.0001) in subjects with hyperreflexia in the lower limbs (1.3 +/- 0.2) than in subjects without any clinical abnormalities (1.7 +/- 0.6), suggesting that subjects with hyperreflexia in the lower limbs already have some immunologic abnormalities. The concordance of HTLV-I infection between husband and wife was lower in this study than in a previous study. HTLV-I-related inflammatory symptoms were more frequent (p =.021, Fisher exact test; OR = 9.5; 95% CI, 1.7-53.5) in HTLV-I tax A-infected donors (3 [50%] of 6 donors) than in HTLV-I tax B-infected donors (10 [9.5%] of 105 donors), suggesting different risks of HTLV-I-related symptoms according to the virus genotype.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1525-4135
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
328-34
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12626894-Adult,
pubmed-meshheading:12626894-Blood Donors,
pubmed-meshheading:12626894-CD4-CD8 Ratio,
pubmed-meshheading:12626894-Disease Transmission, Infectious,
pubmed-meshheading:12626894-Family Health,
pubmed-meshheading:12626894-Genes, pX,
pubmed-meshheading:12626894-HTLV-I Infections,
pubmed-meshheading:12626894-Human T-lymphotropic virus 1,
pubmed-meshheading:12626894-Humans,
pubmed-meshheading:12626894-Japan,
pubmed-meshheading:12626894-Leg,
pubmed-meshheading:12626894-Male,
pubmed-meshheading:12626894-Middle Aged,
pubmed-meshheading:12626894-Paraparesis, Tropical Spastic,
pubmed-meshheading:12626894-Proviruses,
pubmed-meshheading:12626894-Reflex, Abnormal,
pubmed-meshheading:12626894-Sexually Transmitted Diseases, Viral,
pubmed-meshheading:12626894-Spouses,
pubmed-meshheading:12626894-Urination Disorders,
pubmed-meshheading:12626894-Uveitis,
pubmed-meshheading:12626894-Viral Load
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Human T-cell lymphotropic virus type I (HTLV-I)-related clinical and laboratory findings for HTLV-I-infected blood donors.
|
| pubmed:affiliation |
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan. furukawy@m2.kufm.kagoshima-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|