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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-3-7
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pubmed:abstractText |
Matrix metalloproteinases (MMPs) play an important role in smooth muscle cell (SMC) migration and proliferation during vascular remodelling. To investigate the expression of MMP-12 by SMCs, we examined the protein secretion and mRNA expression of MMP-12 by cultured medial SMCs and intimal SMCs derived from human aortic atherosclerotic lesions. To further elucidate the molecular mechanism for MMP-12 expression in SMCs, we determined the sequence requirements for MMP-12 gene transcriptional activity.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1356-9597
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-34
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12622720-Electrophoresis,
pubmed-meshheading:12622720-Humans,
pubmed-meshheading:12622720-Matrix Metalloproteinase 12,
pubmed-meshheading:12622720-Metalloendopeptidases,
pubmed-meshheading:12622720-Muscle, Smooth, Vascular,
pubmed-meshheading:12622720-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:12622720-Promoter Regions, Genetic,
pubmed-meshheading:12622720-RNA, Messenger,
pubmed-meshheading:12622720-Signal Transduction
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.
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|
pubmed:affiliation |
Department of Pathology, Institute of Basical Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article
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