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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-3-6
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pubmed:abstractText |
ETS proteins (such as PU.1, Fli-1 and ETS-1) have been shown to play important roles in normal and abnormal hematopoiesis. We examined the expression of the ELF subfamily of ETS genes (ELF-1, MEF and NERF) in acute myeloid leukemia (AML) cells using Northern blot analysis. ELF-1 and MEF were expressed in all samples, whereas NERF was not. The relative expression (RE) of MEF, but not ELF-1, was significantly lower (P<0.0001) in AML with t(8;21) and t(15;17) compared with AML with normal karyotype. The pattern of MEF expression was not uniform among cells with CD34(+)/CD33(+). It is suggested that the low RE of MEF might be part of a gene expression profile characterizing AML with a good prognosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ELF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ELF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12620289-Acute Disease,
pubmed-meshheading:12620289-Adult,
pubmed-meshheading:12620289-Aged,
pubmed-meshheading:12620289-Chromosomes, Human, Pair 15,
pubmed-meshheading:12620289-Chromosomes, Human, Pair 17,
pubmed-meshheading:12620289-Chromosomes, Human, Pair 21,
pubmed-meshheading:12620289-Chromosomes, Human, Pair 8,
pubmed-meshheading:12620289-DNA-Binding Proteins,
pubmed-meshheading:12620289-Female,
pubmed-meshheading:12620289-Gene Expression Regulation, Leukemic,
pubmed-meshheading:12620289-Hematopoietic Stem Cells,
pubmed-meshheading:12620289-Humans,
pubmed-meshheading:12620289-Karyotyping,
pubmed-meshheading:12620289-Leukemia, Myeloid,
pubmed-meshheading:12620289-Male,
pubmed-meshheading:12620289-Middle Aged,
pubmed-meshheading:12620289-Prognosis,
pubmed-meshheading:12620289-RNA, Messenger,
pubmed-meshheading:12620289-RNA, Neoplasm,
pubmed-meshheading:12620289-Transcription Factors,
pubmed-meshheading:12620289-Translocation, Genetic,
pubmed-meshheading:12620289-Tumor Markers, Biological
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pubmed:year |
2003
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pubmed:articleTitle |
The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases.
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pubmed:affiliation |
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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