Source:http://linkedlifedata.com/resource/pubmed/id/12618278
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-3-5
|
| pubmed:abstractText |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) is associated with increased transmembrane signal transduction via adenylyl cyclase inhibiting G (G(i)) proteins. We tested whether GNB3 C825T is associated with an increased risk of coronary artery disease (CAD). Genotypes were determined with polymerase chain reaction and allele-specific fluorogenic probes. Angiographically examined, consecutive patients (n=998) with CAD and angiographically examined, sex- and age-matched controls (n=340) with no evidence of CAD were studied. The proportion of T allele carriers was significantly higher in the group with CAD compared with the control group (55.6 vs. 48.5; P=0.02). T allele carriage was associated with a 33% increase in the unadjusted risk (OR 1.33 [95% confidence interval, 1.04-1.70]) and a 37% increase in the adjusted risk (OR from the multivariate model 1.37 [95% CI, 1.06-1.76]) for CAD. Moreover, an increase in T allele carriage was associated with an increase in disease severity (P=0.006; test for trend). The strongest association was observed between T allele carriage and three-vessel disease (unadjusted OR 1.47 [95% CI, 1.10-1.96]). Thus, carrying this allele is associated with the presence as well as the severity of CAD.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
|
| pubmed:issn |
0021-9150
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
167
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
135-9
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:12618278-Aged,
pubmed-meshheading:12618278-Alleles,
pubmed-meshheading:12618278-Base Sequence,
pubmed-meshheading:12618278-Case-Control Studies,
pubmed-meshheading:12618278-Coronary Artery Disease,
pubmed-meshheading:12618278-Female,
pubmed-meshheading:12618278-Genetic Predisposition to Disease,
pubmed-meshheading:12618278-Genotype,
pubmed-meshheading:12618278-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:12618278-Heterozygote,
pubmed-meshheading:12618278-Humans,
pubmed-meshheading:12618278-Logistic Models,
pubmed-meshheading:12618278-Male,
pubmed-meshheading:12618278-Middle Aged,
pubmed-meshheading:12618278-Molecular Sequence Data,
pubmed-meshheading:12618278-Polymerase Chain Reaction,
pubmed-meshheading:12618278-Polymorphism, Genetic,
pubmed-meshheading:12618278-Probability,
pubmed-meshheading:12618278-Reference Values,
pubmed-meshheading:12618278-Risk Assessment,
pubmed-meshheading:12618278-Severity of Illness Index
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
G protein beta 3 subunit 825T allele carriage and risk of coronary artery disease.
|
| pubmed:affiliation |
Deutsches Herzzentrum München and 1. Medizinische Klinik rechts der Isar, Technische Universität München, Lazarettstr. 36, Germany. beckerath@dhm.mhn.de
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|