|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0015127,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0032174,
umls-concept:C0141313,
umls-concept:C0178324,
umls-concept:C0205145,
umls-concept:C0205314,
umls-concept:C0439590,
umls-concept:C0679622,
umls-concept:C1314792
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|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2003-3-5
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|
pubmed:abstractText |
Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0008-6363
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
57
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
853-60
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:12618247-Angioplasty, Balloon,
pubmed-meshheading:12618247-Animals,
pubmed-meshheading:12618247-Blood Platelets,
pubmed-meshheading:12618247-Blood Pressure,
pubmed-meshheading:12618247-Carotid Artery, Common,
pubmed-meshheading:12618247-Carotid Artery Injuries,
pubmed-meshheading:12618247-Male,
pubmed-meshheading:12618247-Microscopy, Electron, Scanning,
pubmed-meshheading:12618247-Nitroglycerin,
pubmed-meshheading:12618247-Penicillamine,
pubmed-meshheading:12618247-Platelet Adhesiveness,
pubmed-meshheading:12618247-Platelet Aggregation,
pubmed-meshheading:12618247-Platelet Aggregation Inhibitors,
pubmed-meshheading:12618247-Rabbits,
pubmed-meshheading:12618247-Vasoconstriction,
pubmed-meshheading:12618247-Vasodilator Agents
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury.
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|
pubmed:affiliation |
Centre for Cardiovascular Science, University of Edinburgh, UK.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
