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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-3-5
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pubmed:abstractText |
Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemical expression of Mel-CAM in 41 parotid MEC was correlated with clinical parameters. Ten cases of oral cavity SCC were included for comparison. Mel-CAM expression was found in 92.7% of the MEC but was not expressed by the SCC. Mel-CAM expression was greater in intermediate/high grade tumors, was weaker in patients that presented local recurrence, regional and distant metastasis, but no correlation between Mel-CAM and clinical stage and survival of the patients was found. Decreased Mel-CAM expression can impair cellular contact properties, facilitating growth, cell spreading and metastasis in MEC. Mel-CAM can also be useful in differentiating high grade MEC from SCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD146,
http://linkedlifedata.com/resource/pubmed/chemical/MCAM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neural Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1368-8375
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12618200-Adolescent,
pubmed-meshheading:12618200-Adult,
pubmed-meshheading:12618200-Aged,
pubmed-meshheading:12618200-Antigens, CD,
pubmed-meshheading:12618200-Antigens, CD146,
pubmed-meshheading:12618200-Carcinoma, Mucoepidermoid,
pubmed-meshheading:12618200-Carcinoma, Squamous Cell,
pubmed-meshheading:12618200-Child,
pubmed-meshheading:12618200-Diagnosis, Differential,
pubmed-meshheading:12618200-Female,
pubmed-meshheading:12618200-Humans,
pubmed-meshheading:12618200-Male,
pubmed-meshheading:12618200-Membrane Glycoproteins,
pubmed-meshheading:12618200-Middle Aged,
pubmed-meshheading:12618200-Neoplasm Proteins,
pubmed-meshheading:12618200-Neoplasm Recurrence, Local,
pubmed-meshheading:12618200-Neural Cell Adhesion Molecules,
pubmed-meshheading:12618200-Parotid Neoplasms,
pubmed-meshheading:12618200-Prognosis,
pubmed-meshheading:12618200-Tumor Markers, Biological
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pubmed:year |
2003
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pubmed:articleTitle |
Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma.
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pubmed:affiliation |
Oral Pathology, School of Dentistry, State University of Rio de Janeiro (UERJ), Boulevard 28 de Setembro, no. 157, CEP: 21550-030, Rio de Janeiro/RJ, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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