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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
5
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pubmed:dateCreated |
2003-3-5
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|
pubmed:abstractText |
The preparation of two novel bis(acridine)platinum(II) complexes is reported. The 4+ charged conjugates associate strongly with double-stranded native DNA (K(i)>10(6)), possibly through bisintercalation. A cell viability assay was used to demonstrate that both compounds are capable of mediating cytotoxicity at micromolar concentrations in SNB19 brain tumor cells.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
10
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
855-8
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12617907-Acridines,
pubmed-meshheading:12617907-Animals,
pubmed-meshheading:12617907-Antineoplastic Agents,
pubmed-meshheading:12617907-Cattle,
pubmed-meshheading:12617907-Cell Survival,
pubmed-meshheading:12617907-DNA,
pubmed-meshheading:12617907-Glioblastoma,
pubmed-meshheading:12617907-Humans,
pubmed-meshheading:12617907-Intercalating Agents,
pubmed-meshheading:12617907-Organoplatinum Compounds,
pubmed-meshheading:12617907-Spectrophotometry, Ultraviolet,
pubmed-meshheading:12617907-Thiourea,
pubmed-meshheading:12617907-Tumor Cells, Cultured
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells.
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pubmed:affiliation |
Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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