The pharmacokinetics of lipid-formulated amphotericin B (AMB), and of AMB that has dissociated from its lipid moiety and bound to lipoproteins in plasma, were separately determined in critically ill patients.
Clinical Pharmacokinetics Unit, Medical Intensive Care Research Laboratory, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. romuald.bellmann@uibk.ac.at