Source:http://linkedlifedata.com/resource/pubmed/id/12615626
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2003-6-10
|
| pubmed:abstractText |
To characterize altered alveolar transfer to solute in bleomycin (BLM)-injured lungs, eight dogs underwent a gadolinium diethylenetriaminepentaacetic acid aerosol (Gd-AS) magnetic resonance imaging study before and on Days 7 and 40 after tracheal instillation of BLM (0.75 mg) in the left lungs. Consecutive fast-gradient echo magnetic resonance imaging was acquired during and after spontaneous inhalation of 200-mM Gd-AS. The slope (Kep) and clearance half-time (T1/2) of logarithmic regression lines for clearance curves were estimated. Histology on Day 40 was compared with that on Day 7 in another three dogs. On Days 7 and 40, Gd-AS deposition was heterogeneously reduced in the affected lungs. On Day 7 with multifocal intraalveolar exudative changes, Kep in affected areas was significantly increased compared with baseline (2.5 x 10(-3) minutes(-1) +/- 0.3 versus 1.7 x 10(-3) minutes(-1) +/- 0.2, p < 0.0001), with significant decrease in T1/2 (121.6 +/- 19.7 minutes vs. 170.4 +/- 15.8 minutes, p < 0.001). However, on Day 40 with multifocal interstitial fibrosis, Kep and T1/2 were recovered toward baseline. BLM-injured lungs can be characterized by accelerated Gd-AS clearance during the acute exudative phase and their recovery during the chronic fibrotic phase. This technique is acceptable for monitoring alveolar transfer changes in BLM-injured lungs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
167
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1704-10
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| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12615626-Acute Disease,
pubmed-meshheading:12615626-Administration, Inhalation,
pubmed-meshheading:12615626-Aerosols,
pubmed-meshheading:12615626-Animals,
pubmed-meshheading:12615626-Bleomycin,
pubmed-meshheading:12615626-Chronic Disease,
pubmed-meshheading:12615626-Contrast Media,
pubmed-meshheading:12615626-Disease Models, Animal,
pubmed-meshheading:12615626-Dogs,
pubmed-meshheading:12615626-Gadolinium DTPA,
pubmed-meshheading:12615626-Instillation, Drug,
pubmed-meshheading:12615626-Linear Models,
pubmed-meshheading:12615626-Magnetic Resonance Imaging,
pubmed-meshheading:12615626-Metabolic Clearance Rate,
pubmed-meshheading:12615626-Pulmonary Alveoli,
pubmed-meshheading:12615626-Respiratory Distress Syndrome, Adult,
pubmed-meshheading:12615626-Severity of Illness Index,
pubmed-meshheading:12615626-Time Factors,
pubmed-meshheading:12615626-Trachea
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Altered clearance of gadolinium diethylenetriaminepentaacetic acid aerosol from bleomycin-injured dog lungs: initial observations.
|
| pubmed:affiliation |
Department of Radiology, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. sugar@po.cc.yamaguchi-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|