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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13-14
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pubmed:dateCreated |
2003-3-4
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pubmed:abstractText |
Bacterial products, including lipopolysaccharide (LPS), are potential impurities in plasmid DNA vaccines. LPS has immunostimulatory properties even at exceedingly low concentrations through activation of Toll-like receptor 4 (TLR4). The potency of T-cell responses after vaccination was tested with DNA containing high LPS or depleted of LPS in TLR4-competent and TLR4-deficient mice. CD8(+) T-cell responses were readily induced in TLR4-deficient mice immunized with DNA depleted of LPS. LPS in DNA vaccines is not required for CD8(+) T-cell responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1548-53
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12615452-Animals,
pubmed-meshheading:12615452-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12615452-Dendritic Cells,
pubmed-meshheading:12615452-Lipopolysaccharides,
pubmed-meshheading:12615452-Membrane Glycoproteins,
pubmed-meshheading:12615452-Mice,
pubmed-meshheading:12615452-Mice, Inbred BALB C,
pubmed-meshheading:12615452-Mice, Inbred C3H,
pubmed-meshheading:12615452-Mice, Inbred C57BL,
pubmed-meshheading:12615452-Receptors, Cell Surface,
pubmed-meshheading:12615452-Toll-Like Receptor 4,
pubmed-meshheading:12615452-Toll-Like Receptors,
pubmed-meshheading:12615452-Vaccination,
pubmed-meshheading:12615452-Vaccines, DNA
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pubmed:year |
2003
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|
pubmed:articleTitle |
The role of lipopolysaccharide in T-cell responses following DNA vaccination.
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|
pubmed:affiliation |
Swim Across America Laboratory, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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