Linked Life Data

12615198

Source:http://linkedlifedata.com/resource/pubmed/id/12615198

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-3-4
pubmed:abstractText
This paper reviews the nature of communication from the immune system to the brain and some implications of this communication for phenomena that are not ordinarily considered to be modulated by immune function. Pro-inflammatory cytokines released by activated immune cells signal the brain by both blood-borne and neural routes, leading to alterations in neural activity. The cascade of altered neural activity includes the induction of pro-inflammatory cytokines within the brain and spinal cord. The cytokines in the brain, specifically in the hippocampus, interfere with the consolidation of memory, while the cytokines within the spinal cord exaggerate pain. Activation of this immune-to-central nervous system pathway, with the consequent production of cytokines within the central nervous system, may be involved in the mediation of a number of phenomena that occur during cancer and cancer treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0889-1591
pubmed:author
pubmed:issnType
Print
pubmed:volume
17 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S125-31
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment.
pubmed:affiliation
Department of Psychology and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder 80309-0345, USA. smaier@psych.colorado.edu
pubmed:publicationType
Journal Article, Review