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pubmed:abstractText |
Tryptophan (TRP), an essential amino acid, is bound mostly to albumin in plasma. However, it is reported that binding is inhibited by indoles that accumulate in uremic plasma. This may be responsible for the malnutrition observed in uremic patients. AST-120, an oral adsorbent of uremic toxins, can reduce concentrations of indoxyl sulfate (IS), the most abundant indolic metabolite in uremic plasma. We therefore investigated whether AST-120 recovers TRP binding to plasma proteins and improves the nutritional state of uremic patients.
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pubmed:affiliation |
Department of Nephrology, Osaka Prefectural General Hospital, 3-1-56 Bandaihigashi, Sumiyoshi-ku, Osaka 558-8558, Japan. cyq06075@nifty.ne.jp
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