| pubmed-article:12612579 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12612579 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12612579 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12612579 | lifeskim:mentions | umls-concept:C2347338 | lld:lifeskim |
| pubmed-article:12612579 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12612579 | pubmed:dateCreated | 2003-3-27 | lld:pubmed |
| pubmed-article:12612579 | pubmed:abstractText | Autoimmune polyendocrinopathy syndrome type 1 is a recessive Mendelian disorder resulting from mutations in a novel gene, AIRE, and is characterized by a spectrum of organ-specific autoimmune diseases. It is not known what tolerance mechanisms are defective as a result of AIRE mutation. By tracing the fate of autoreactive CD4+ T cells with high affinity for a pancreatic antigen in transgenic mice with an Aire mutation, we show here that Aire deficiency causes almost complete failure to delete the organ-specific cells in the thymus. These results indicate that autoimmune polyendocrinopathy syndrome 1 is caused by failure of a specialized mechanism for deleting forbidden T cell clones, establishing a central role for this tolerance mechanism. | lld:pubmed |
| pubmed-article:12612579 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12612579 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12612579 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12612579 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12612579 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12612579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12612579 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12612579 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12612579 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:12612579 | pubmed:author | pubmed-author:PeltonenLeena... | lld:pubmed |
| pubmed-article:12612579 | pubmed:author | pubmed-author:GoodnowChrist... | lld:pubmed |
| pubmed-article:12612579 | pubmed:author | pubmed-author:LesageSylvieS | lld:pubmed |
| pubmed-article:12612579 | pubmed:author | pubmed-author:WilsonJudithJ | lld:pubmed |
| pubmed-article:12612579 | pubmed:author | pubmed-author:ListonAdrianA | lld:pubmed |
| pubmed-article:12612579 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12612579 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12612579 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12612579 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12612579 | pubmed:pagination | 350-4 | lld:pubmed |
| pubmed-article:12612579 | pubmed:dateRevised | 2007-11-8 | lld:pubmed |
| pubmed-article:12612579 | pubmed:meshHeading | pubmed-meshheading:12612579... | lld:pubmed |
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| pubmed-article:12612579 | pubmed:meshHeading | pubmed-meshheading:12612579... | lld:pubmed |
| pubmed-article:12612579 | pubmed:meshHeading | pubmed-meshheading:12612579... | lld:pubmed |
| pubmed-article:12612579 | pubmed:meshHeading | pubmed-meshheading:12612579... | lld:pubmed |
| pubmed-article:12612579 | pubmed:meshHeading | pubmed-meshheading:12612579... | lld:pubmed |
| pubmed-article:12612579 | pubmed:meshHeading | pubmed-meshheading:12612579... | lld:pubmed |
| pubmed-article:12612579 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12612579 | pubmed:articleTitle | Aire regulates negative selection of organ-specific T cells. | lld:pubmed |
| pubmed-article:12612579 | pubmed:affiliation | ACRF Genetics Lab, Medical Genome Centre, John Curtin School of Medical Research, The Australian National University, ACT 2601 Australia. | lld:pubmed |
| pubmed-article:12612579 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12612579 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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