| pubmed-article:12612073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C0080298 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C0034833 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C0033308 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12612073 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:12612073 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12612073 | pubmed:dateCreated | 2003-3-3 | lld:pubmed |
| pubmed-article:12612073 | pubmed:abstractText | In breast cancer cells, estrogens activate the Src/Erk pathway through an interaction of the estrogen receptor alpha (ERalpha) with the SH2 domain of c-Src. Progestins have been reported to activate also this pathway either via an interaction of the progesterone receptor isoform B (PRB) with ERalpha, which itself activates c-Src, or by direct interaction of PRB with the SH3 domain of c-Src. Here we identify two domains of PRB, ERID-I and -II, mediating a direct interaction with the ligand-binding domain of ERalpha. ERID-I and ERID-II flank a proline cluster responsible for binding of PRB to c-Src. In mammalian cells, the interaction of PRB with ERalpha and the progestin activation of the Src/Erk cascade are abolished by deletion of either ERID-I or ERID-II. These regions are not required for transactivation of a progesterone-responsive reporter gene. Mutations in the proline cluster of PRB that prevent a direct interaction with c-Src do not affect the strong activation of c-Src by progestins in the presence of ERalpha. Thus, in cells with ERalpha, ERID-I and ERID-II are necessary and sufficient for progestin activation of the endogenous Src/Erk pathway. | lld:pubmed |
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| pubmed-article:12612073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12612073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12612073 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12612073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12612073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12612073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12612073 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12612073 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:BeatoMiguelM | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:AuricchioFerd... | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:SanchoElenaE | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:BallaréCecili... | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:UhrigMarkusM | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:BechtoldThoma... | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:12612073 | pubmed:author | pubmed-author:MigliaccioAnt... | lld:pubmed |
| pubmed-article:12612073 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12612073 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12612073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12612073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12612073 | pubmed:pagination | 1994-2008 | lld:pubmed |
| pubmed-article:12612073 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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