Linked Life Data

12610717

Source:http://linkedlifedata.com/resource/pubmed/id/12610717

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2003-10-7
pubmed:abstractText
Latent inhibition (LI) is the delayed learning of an association when the conditioned stimulus has previously been experienced out of the context of that association. LI can be measured across species and has been used to understand the neurobiology of schizophrenia, since some reports suggest that schizophrenia patients exhibit LI deficits. One challenge of LI studies in humans has resulted from the fact that LI paradigms have almost uniformly involved between-subject comparisons. We now report a new within-subject paradigm that detected LI in normal adult male subjects after ingestion of a placebo. After amphetamine (20 mg p.o.) or bromocriptine (1.25 mg p.o.), LI was not evident, suggesting that the LI detected by this paradigm is sensitive to disruption by dopamine agonists. The apparent advantages and limitations of this paradigm are discussed with regard to its future use in understanding the neural basis of reported LI deficits in schizophrenia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
314-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Dopamine agonists disrupt visual latent inhibition in normal males using a within-subject paradigm.
pubmed:affiliation
Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr., La Jolla, CA 92093-0804, USA. nswerdlow@ucsd.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.