Source:http://linkedlifedata.com/resource/pubmed/id/12610650
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-2-28
|
| pubmed:abstractText |
Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/proband trios in which RD was rigorously defined. The most significant replicated associations were observed between combinations of markers D6S109/422/1665 (Stage 1, P=0.002 (adjusted for multiple testing); Stage 2, P=0.0001) and D6S506/1029/1660 (Stage 1, P=0.02 (adjusted), Stage 2, P=0.0001). The only two-marker association observed in both samples was with D6S422/1665 (P=0.01, 0.04). No single marker showed replicated association but D6S506 produced values of P=0.01 and 0.08 which were significant when combined (P=0.02). We observed weaker and less consistent evidence of association in a region of confirmed linkage to RD in previous studies. The most consistently significant haplotypic association D6S109/422/1665, showed association with single-word reading, spelling, phonological awareness, phonological decoding, orthographic accuracy and random automised naming, but not with vocabulary or Attention Deficit Hyperactivity Disorder. Our findings strongly support the presence of a gene contributing to RD in a region of chromosome 6 between markers D6S109 and D6S1260, but do not rule out the presence of a gene between D6S1556 and MOG.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1359-4184
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| pubmed:author |
pubmed-author:ChowdhuryRR,
pubmed-author:DukeMM,
pubmed-author:EastonMM,
pubmed-author:FernandoSS,
pubmed-author:GriersonAA,
pubmed-author:GruenJJ,
pubmed-author:HamshereMM,
pubmed-author:HopkinEE,
pubmed-author:KrawczakMM,
pubmed-author:MilhamCC,
pubmed-author:MorrisD WDW,
pubmed-author:NIWACC,
pubmed-author:O'DonovanM CMC,
pubmed-author:PoundKK,
pubmed-author:RobinsonLL,
pubmed-author:StevensonJJ,
pubmed-author:TuricDD,
pubmed-author:Van Den BreeMM,
pubmed-author:WebbVV,
pubmed-author:WilliamsJJ,
pubmed-author:WilliamsNN
|
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
176-85
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12610650-Adolescent,
pubmed-meshheading:12610650-Child,
pubmed-meshheading:12610650-Child, Preschool,
pubmed-meshheading:12610650-Chromosomes, Human, Pair 6,
pubmed-meshheading:12610650-Dyslexia,
pubmed-meshheading:12610650-Family Health,
pubmed-meshheading:12610650-Haplotypes,
pubmed-meshheading:12610650-Humans,
pubmed-meshheading:12610650-Linkage Disequilibrium,
pubmed-meshheading:12610650-Microsatellite Repeats,
pubmed-meshheading:12610650-Phenotype
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.
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| pubmed:affiliation |
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|