|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2003-2-28
|
|
pubmed:abstractText |
Endoplasmic reticulum (ER) was recently suggested as a third subcellular compartment in apoptotic execution. Survivin is a member of inhibitors of apoptosis and ursodeoxycholic acid (UDCA) prevents apoptosis from various apoptotic stimuli. To assess the activity of survivin and the effect of UDCA on the survivin in ER stress-mediated apoptosis, we treated hepatoma cell lines with thapsigargin (TG). TG-induced apoptosis was assessed by morphological changes, DNA fragmentation, cleavages of poly(ADP-ribose)polymerase (PARP), and activation of calpain and caspase-12. The level of survivin was decreased after TG treatment in hepatoma cell lines indicating that survivin play an important role in ER stress-mediated apoptosis. UDCA prevented decrease in survivin levels and inhibited TG-induced apoptosis and caspase-12 activation suggesting an anti-apoptotic effect of UDCA.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calpain,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 12,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin,
http://linkedlifedata.com/resource/pubmed/chemical/Ursodeoxycholic Acid
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0304-3835
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
28
|
|
pubmed:volume |
191
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
83-92
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12609713-Apoptosis,
pubmed-meshheading:12609713-Calpain,
pubmed-meshheading:12609713-Carcinoma, Hepatocellular,
pubmed-meshheading:12609713-Caspase 12,
pubmed-meshheading:12609713-Caspases,
pubmed-meshheading:12609713-DNA Fragmentation,
pubmed-meshheading:12609713-Endoplasmic Reticulum,
pubmed-meshheading:12609713-Enzyme Activation,
pubmed-meshheading:12609713-Genes, bcl-2,
pubmed-meshheading:12609713-Humans,
pubmed-meshheading:12609713-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:12609713-Liver Neoplasms,
pubmed-meshheading:12609713-Microtubule-Associated Proteins,
pubmed-meshheading:12609713-Neoplasm Proteins,
pubmed-meshheading:12609713-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:12609713-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12609713-Stress, Physiological,
pubmed-meshheading:12609713-Thapsigargin,
pubmed-meshheading:12609713-Tumor Cells, Cultured,
pubmed-meshheading:12609713-Ursodeoxycholic Acid
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
The effect of ursodeoxycholic acid on the survivin in thapsigargin-induced apoptosis.
|
|
pubmed:affiliation |
Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center (151B), 2002 Holcombe Boulevard, Houston, TX 77030, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
