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12608875
Source:
http://linkedlifedata.com/resource/pubmed/id/12608875
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0001128
,
umls-concept:C0043481
,
umls-concept:C0443286
,
umls-concept:C0532362
pubmed:issue
2
pubmed:dateCreated
2003-2-28
pubmed:abstractText
Reaction of antitumor agent irofulven (1) with zinc and acetic acid yielded several new indene derivatives (6, 7, 8, 10) as well as the known indene (9). These all have greatly reduced toxicity to human leukemia (HL60) cells compared to irofulven.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/7906882
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acid
,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating
,
http://linkedlifedata.com/resource/pubmed/chemical/Indenes
,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents
,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes
,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc
,
http://linkedlifedata.com/resource/pubmed/chemical/irofulven
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0163-3864
pubmed:author
pubmed-author:KelnerMichael JMJ
,
pubmed-author:McMorrisTrevor CTC
,
pubmed-author:MoonSurk-SikSS
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
310-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12608875-Acetic Acid
,
pubmed-meshheading:12608875-Antineoplastic Agents, Alkylating
,
pubmed-meshheading:12608875-Chromatography, Thin Layer
,
pubmed-meshheading:12608875-Drug Screening Assays, Antitumor
,
pubmed-meshheading:12608875-HL-60 Cells
,
pubmed-meshheading:12608875-Humans
,
pubmed-meshheading:12608875-Indenes
,
pubmed-meshheading:12608875-Indicators and Reagents
,
pubmed-meshheading:12608875-Inhibitory Concentration 50
,
pubmed-meshheading:12608875-Molecular Structure
,
pubmed-meshheading:12608875-Nuclear Magnetic Resonance, Biomolecular
,
pubmed-meshheading:12608875-Sesquiterpenes
,
pubmed-meshheading:12608875-Zinc
pubmed:year
2003
pubmed:articleTitle
Reaction of irofulven with zinc and acid.
pubmed:affiliation
Department of Chemistry, University of California, San Diego, La Jolla, California 92093-0506, USA. tmcmorris@ucsd.edu
pubmed:publicationType
Journal Article
,
Comparative Study