Linked Life Data

12606697

Source:http://linkedlifedata.com/resource/pubmed/id/12606697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-4-21
pubmed:abstractText
Corticotropin-releasing factor (CRF) plays a preeminent role in coordinating the endocrine, autonomic, and behavioral responses to stress. Dysregulation of both hypothalamic and extrahypothalamic CRF systems have been reported in patients with major depression and post-traumatic stress disorder. Moreover, effective treatment of these conditions leads to normalization of these CRF systems. Although there is virtually no data concerning alterations of CRF systems in bipolar disorder (manic depressive illness), previous work indicates that valproic acid, an anticonvulsant also effective in the treatment of acute mania, alters central CRF neuronal systems. In the current studies, we chronically administered valproic acid and lithium, two clinically effective mood stabilizers, in nonstressed rats to extend our previous findings. Chronic valproic acid administration decreased CRF mRNA expression in the paraventricular nucleus of the hypothalamus; lithium administration increased CRF mRNA expression in the central nucleus of the amygdala. Although valproic acid increased CRF(1) receptor mRNA expression in the cortex, CRF(1) receptor binding was decreased in both the basolateral amygdala and cortex, suggesting that chronic valproate treatment may in fact dampen the overall tone in this central stress pathway. Valproate treatment decreased CRF(2A) mRNA expression in both the lateral septum and hypothalamus, although CRF(2A) receptor binding was unchanged. Lithium administration decreased CRF(1) mRNA expression in both the amygdala and frontal cortex, but CRF(1) receptor binding also remained unchanged. These results suggest that the therapeutic actions of these mood stabilizers may, in part, result from their actions on central CRF neuronal systems. The distinct actions of each drug on CRF systems may underlie their synergistic clinical effects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
305
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
434-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12606697-Adrenocorticotropic Hormone, pubmed-meshheading:12606697-Animals, pubmed-meshheading:12606697-Antimanic Agents, pubmed-meshheading:12606697-Autoradiography, pubmed-meshheading:12606697-Corticosterone, pubmed-meshheading:12606697-Corticotropin-Releasing Hormone, pubmed-meshheading:12606697-Hypothalamo-Hypophyseal System, pubmed-meshheading:12606697-Image Processing, Computer-Assisted, pubmed-meshheading:12606697-In Situ Hybridization, pubmed-meshheading:12606697-Lithium Carbonate, pubmed-meshheading:12606697-Male, pubmed-meshheading:12606697-Neurons, pubmed-meshheading:12606697-RNA, Messenger, pubmed-meshheading:12606697-Radioimmunoassay, pubmed-meshheading:12606697-Rats, pubmed-meshheading:12606697-Rats, Sprague-Dawley, pubmed-meshheading:12606697-Urocortins, pubmed-meshheading:12606697-Valproic Acid, pubmed-meshheading:12606697-Weight Gain
pubmed:year
2003
pubmed:articleTitle
The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr., WMB Suite 4000, Atlanta, GA 30322, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't