Linked Life Data

12606530

Source:http://linkedlifedata.com/resource/pubmed/id/12606530

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-2-27
pubmed:abstractText
The IGF system has been associated with development and progression of diabetic retinopathy. We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. A prospective observational study was performed in 103 pregnant women with type 1 diabetes. Serum IGF-I was measured in maternal serum from week 14, every fourth week until week 30, and every second week until delivery. Twenty-four-hour blood pressure was measured with a portable oscillometry monitor. The women had visual acuity testing and fundus photography before pregnancy, once in each trimester, and 4 months after birth. Each eye was assigned an overall retinopathy grade on a scale from 1 to 6 independently by two experienced graders. During pregnancy, serum IGF-I increased with increasing gestational age until a plateau was reached in week 32. Progression of retinopathy was significantly associated with a higher level of IGF-I (P < 0.01). Serum IGF-I increased with increasing progression of retinopathy. Change of retinopathy was significantly associated with level of IGF-I (P < 0.01). During pregnancy, serum IGF-I increased with increasing birth weight until a plateau was reached in week 32. Birth weight was significantly associated with a higher level of serum IGF-I (P < 0.01).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
852-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12606530-Adult, pubmed-meshheading:12606530-Birth Weight, pubmed-meshheading:12606530-Body Mass Index, pubmed-meshheading:12606530-Diabetes Mellitus, Type 1, pubmed-meshheading:12606530-Diabetic Retinopathy, pubmed-meshheading:12606530-Diagnostic Techniques, Ophthalmological, pubmed-meshheading:12606530-Female, pubmed-meshheading:12606530-Gestational Age, pubmed-meshheading:12606530-Hemoglobin A, Glycosylated, pubmed-meshheading:12606530-Humans, pubmed-meshheading:12606530-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:12606530-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:12606530-Insulin-Like Growth Factor I, pubmed-meshheading:12606530-Pregnancy, pubmed-meshheading:12606530-Pregnancy in Diabetics, pubmed-meshheading:12606530-Prospective Studies, pubmed-meshheading:12606530-Visual Acuity
pubmed:year
2003
pubmed:articleTitle
Increased serum IGF-I during pregnancy is associated with progression of diabetic retinopathy.
pubmed:affiliation
Department of Obstetrics/Gynecology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark. affl@ringamt.dk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't