Source:http://linkedlifedata.com/resource/pubmed/id/12606515
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2003-2-27
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| pubmed:abstractText |
Uteroplacental insufficiency resulting in fetal growth retardation is a common complication of pregnancy and a significant cause of perinatal morbidity and mortality. Epidemiological studies show an increased incidence of type 2 diabetes in humans who were growth retarded at birth. The mechanisms by which an abnormal intrauterine milieu leads to the development of diabetes in adulthood are not known. Therefore, a rat model of uteroplacental insufficiency was developed; intrauterine growth-retarded (IUGR) rats develop diabetes with a phenotype similar to that observed in the human with type 2 diabetes. We show here that administration of a pancreatic beta-cell trophic factor, exendin-4 (Ex-4), during the prediabetic neonatal period dramatically prevents the development of diabetes in this model. This occurs because neonatal Ex-4 prevents the progressive reduction in insulin-producing beta-cell mass that is observed in IUGR rats over time. Expression of PDX, a critical regulator of pancreas development and islet differentiation, is restored to normal levels, and islet beta-cell proliferation rates are normalized by the neonatal Ex-4 treatment. These results indicate that exposure to Ex-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of diabetes in adulthood.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/exenatide,
http://linkedlifedata.com/resource/pubmed/chemical/pancreatic and duodenal homeobox 1...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0012-1797
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
734-40
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| pubmed:dateRevised |
2011-6-1
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| pubmed:meshHeading |
pubmed-meshheading:12606515-Animals,
pubmed-meshheading:12606515-Animals, Newborn,
pubmed-meshheading:12606515-Blood Glucose,
pubmed-meshheading:12606515-Cell Differentiation,
pubmed-meshheading:12606515-Cell Division,
pubmed-meshheading:12606515-Diabetes Mellitus, Type 2,
pubmed-meshheading:12606515-Female,
pubmed-meshheading:12606515-Fetal Growth Retardation,
pubmed-meshheading:12606515-Gene Expression,
pubmed-meshheading:12606515-Glucose Intolerance,
pubmed-meshheading:12606515-Glucose Tolerance Test,
pubmed-meshheading:12606515-Homeodomain Proteins,
pubmed-meshheading:12606515-Homeostasis,
pubmed-meshheading:12606515-Islets of Langerhans,
pubmed-meshheading:12606515-Peptides,
pubmed-meshheading:12606515-Placental Insufficiency,
pubmed-meshheading:12606515-Pregnancy,
pubmed-meshheading:12606515-RNA, Messenger,
pubmed-meshheading:12606515-Rats,
pubmed-meshheading:12606515-Rats, Sprague-Dawley,
pubmed-meshheading:12606515-Trans-Activators,
pubmed-meshheading:12606515-Venoms
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| pubmed:year |
2003
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| pubmed:articleTitle |
Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.
|
| pubmed:affiliation |
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Clinical Research Building 611B, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA. stoffers@mail.med.upenn.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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