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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-3-5
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pubmed:abstractText |
HIV-1 infection in the brain induces neuronal apoptosis leading to HIV-associated dementia. To explore the underlying mechanism, we developed a murine model by using human peripheral blood mononuclear cell (PBMC)-transplanted nonobese diabetic (NOD)-severe combined immunodeficiency (SCID) (hu-PBMC-NOD-SCID) mice. Administration of lipopolysaccharide (LPS) to HIV-1-infected hu-PBMC-NOD-SCID mice induced infiltration of HIV-1-infected human cells into the perivascular region of the brain and neuronal apoptosis was found in macrophage (M)-tropic but not T cell (T)-tropic HIV-1-infected brains. The apoptotic neurons were frequently colocalized with the HIV-1-infected macrophages that expressed tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Administration of a neutralizing antibody against human TRAIL but not human TNF-alpha or Fas ligand (FasL) blocked the neuronal apoptosis in the HIV-1-infected brain. These results strongly suggest a critical contribution of TRAIL expressed on HIV-1-infected macrophages to neuronal apoptosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-10072506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-10209050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-11022932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-11085571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-11238596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-11304551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-11309629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-11385301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-11844843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-1279978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-1371918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-1669703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-3016298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-3016903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-3646751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-7477730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-7500022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-7680963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-7715839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-7877652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-8558009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-8780406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-8943077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-9032379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-9220468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-9229134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-9242611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12601160-9616211
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:InagakiYoshioY,
pubmed-author:ItoMamoruM,
pubmed-author:KawanoYujiY,
pubmed-author:KoyanagiYoshioY,
pubmed-author:MisawaNaokoN,
pubmed-author:MiuraYoshiharuY,
pubmed-author:MizusawaHidehiroH,
pubmed-author:OkadaHiroshiH,
pubmed-author:OkumuraKoK,
pubmed-author:YagitaHideoH,
pubmed-author:YamamotoNaokiN
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2777-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12601160-Humans,
pubmed-meshheading:12601160-Animals,
pubmed-meshheading:12601160-Mice,
pubmed-meshheading:12601160-Brain,
pubmed-meshheading:12601160-Neurons,
pubmed-meshheading:12601160-Lipopolysaccharides,
pubmed-meshheading:12601160-Central Nervous System,
pubmed-meshheading:12601160-Macrophages,
pubmed-meshheading:12601160-Time Factors,
pubmed-meshheading:12601160-Disease Models, Animal,
pubmed-meshheading:12601160-Immunohistochemistry,
pubmed-meshheading:12601160-Cell Death,
pubmed-meshheading:12601160-Antibodies, Monoclonal,
pubmed-meshheading:12601160-Apoptosis,
pubmed-meshheading:12601160-Membrane Glycoproteins,
pubmed-meshheading:12601160-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12601160-HIV-1,
pubmed-meshheading:12601160-HIV Infections,
pubmed-meshheading:12601160-Mice, Inbred NOD,
pubmed-meshheading:12601160-Mice, SCID,
pubmed-meshheading:12601160-Apoptosis Regulatory Proteins,
pubmed-meshheading:12601160-Fas Ligand Protein,
pubmed-meshheading:12601160-In Situ Nick-End Labeling
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