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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-2-25
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pubmed:abstractText |
The authors compared the functional activation state and cytokine secretion profile of CD8+ T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in normal controls. In addition, they examined cytokine secretion in relationship to single nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with SPMS as compared to normal controls. The authors found no significant differences in SNP frequency or in secretion of other cytokines.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1526-632X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
702-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12601116-Adult,
pubmed-meshheading:12601116-Antibodies,
pubmed-meshheading:12601116-Antigens, CD3,
pubmed-meshheading:12601116-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12601116-Cell Division,
pubmed-meshheading:12601116-Cell Separation,
pubmed-meshheading:12601116-Cells, Cultured,
pubmed-meshheading:12601116-Cytokines,
pubmed-meshheading:12601116-Female,
pubmed-meshheading:12601116-Flow Cytometry,
pubmed-meshheading:12601116-Gene Frequency,
pubmed-meshheading:12601116-Humans,
pubmed-meshheading:12601116-Lymphotoxin-alpha,
pubmed-meshheading:12601116-Male,
pubmed-meshheading:12601116-Middle Aged,
pubmed-meshheading:12601116-Multiple Sclerosis, Chronic Progressive,
pubmed-meshheading:12601116-Multiple Sclerosis, Relapsing-Remitting,
pubmed-meshheading:12601116-Polymorphism, Single Nucleotide,
pubmed-meshheading:12601116-Reference Values
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pubmed:year |
2003
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pubmed:articleTitle |
Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.
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pubmed:affiliation |
Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial
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