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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1976-7-6
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pubmed:abstractText |
1. Specific radioimmunoassays for the prostaglandins E2, F2alpha and A2 and the metabolites 13,14-dihydro-15-keto-prostaglandin E2, 15-keto-prostaglandin F2alpha and 13,14-dihydro-15-keto-prostaglandin F2alpha were used to study the metabolism of prostaglandins by gastroscopically obtained small biopsy specimens of human gastric fundus mucosa. 2. Three prostaglandin-metabolizing enzymes were found in the 100 000 X g supernatant of human gastric fundus mucosa, 15-hydroxy-prostaglandin-dehydrogenase, delta13-reductase and delta9-reductase. The specific activity was highest for 15-hydroxy-prostaglandin-dehydrogenase and lowest for delta9-reductase. 3. Formation of prostaglandin A2 (or B2) was not observed under the same conditions. 4. None of the three enzyme activities detected in the 100 000 X g supernatant was found in the 10 000 X g and 100 000 X g pellets of human gastric fundus mucosa. 5. The results indicate that high speed supernatant derived from human gastric mucosa can rapidly metabolize prostaglandin E2 and prostaglandin F2alpha to the 15-keto and 13,14-dihydro-15-keto-derivatives. Furthermore, prostaglandin E2 can be converted to prostaglandin F2alpha, the biological activity of which, on gastric functions, differs from that of prostaglandin E2.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
424
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
430-8
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pubmed:dateRevised |
2009-11-3
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pubmed:meshHeading |
pubmed-meshheading:1259969-Adult,
pubmed-meshheading:1259969-Aged,
pubmed-meshheading:1259969-Female,
pubmed-meshheading:1259969-Gastric Mucosa,
pubmed-meshheading:1259969-Humans,
pubmed-meshheading:1259969-Kinetics,
pubmed-meshheading:1259969-Male,
pubmed-meshheading:1259969-Middle Aged,
pubmed-meshheading:1259969-Prostaglandins A,
pubmed-meshheading:1259969-Prostaglandins E,
pubmed-meshheading:1259969-Prostaglandins F
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pubmed:year |
1976
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pubmed:articleTitle |
On the metabolism of prostaglandins by human gastric fundus mucosa.
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pubmed:publicationType |
Journal Article
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